ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MYNPYQQQGM GYQQQQQQQQ QQPNGFYPQQ QQGQSSNQPQ GQPQPQQQMA FNQPQATGIG 

        70         80         90        100        110        120 
GMPQSFGNSF SSMPQQPQTG YNNNGNNGSV YGNGNFGQQP QQQQQQAKPQ HTGYVPNSSM 

       130        140        150        160        170        180 
PMMNTTGTMP PPNPAQQPQL QSIQPQGTGY YQAANTANVH SVQPLQSQGT GYYVSTPNLI 

       190        200        210        220        230        240 
SSNQTQQPLQ AQGTGYYQSQ PQQVPPPQQA QSLQPLKPQQ TGFYLQPQNQ APLEPLKPTA 

       250        260        270        280        290        300 
TGFVNSFANN GLNNDIKIPA IRLSFITAQD QAKFETLFRS IVTNGSNTVS GANCRKILMR 

       310        320        330        340        350        360 
SGLPPSQLAR IWTLCDTSKA GELLFPEFAL AMHLINDVLQ GDTIPYELDS KTKNEVSSFI 

       370        380        390        400        410        420 
DAINLSIANQ DSSANDAPKT PFDEFITAGV QNLQPQPTGY MPQTSFGIPL QSQITGGGVA 

       430        440        450        460        470        480 
SALNPQSTGF MAPTTFNMSM NTGTPGLNPQ ITGGAPASMQ PNITGNALQP QTTGMMPQTT 

       490        500        510        520        530        540 
GMMPQTTGMM PQTSFGVNLG PQLTGGALQS QYTGGYGSVM PQQSGPASMP NLSFNQQGLQ 

       550        560        570        580        590        600 
SQLTGLQPQP TGFLPPSNFS ATMPLTAQKT GFGNNEIYTK SNFNNNLIDN SSQDKISTEE 

       610        620        630        640        650        660 
KSLFYKIFET FDTQNKGLLD SPTAVEIFRK SGLNRADLEQ IWNLCDINNT GQLNKQEFAL 

       670        680        690        700        710        720 
GMHLVYGKLN GKPIPNVLPS SLIPSSTKLL DNLKNQLKTE PTTTKEKPSF GKIDALSYKN 

       730        740        750        760        770        780 
NDDDVLPNYR NRRKVYSAKN EEQSSFSSPS AKSVNHSSST LQTDDISVDK TVEKKTAKPK 

       790        800        810        820        830        840 
YAGFSREINL KNIASLENEI KNISNPENCY DSSIPSDLTS RFDAIIAKLP NLFNEISTID 

       850        860        870        880        890        900 
NEITNAKIQL YRKKNPSSII GSGPNGEITE NDRKKAKSRA LLRARMSALT GKSTESEDSL 

       910        920        930        940        950        960 
SMEDEQQSAE IKRIQQENGK NQEIIKDIRS SISDISASLK STMTGSNMIS NQEFERWEFG 

       970        980        990       1000       1010       1020 
IGLEDGVREF LDDLKSNSNK SVTESSPFVP SSTPTPVDDR SSSPSYSQFK TAEERAAYLK 

      1030       1040       1050       1060       1070       1080 
EQAKKRMKEK LAKFDKNRRN VTQSSRSISS ENSREQPQQI AGSSNLVEPR ATPFQEEKYV 

      1090       1100       1110       1120       1130       1140 
EVAQPTQPVQ STQPVQPTQP VQPTQPVQPT QPVQPTQPVQ PTQPVQNVYN AKQESDDEDE 

      1150       1160       1170       1180       1190       1200 
DDEEKRLQEE LKRLKLKKKA DKEKRLAALR KQIEDAQNES DEEETNGKDN FGGHVNVPQA 

      1210       1220       1230       1240       1250       1260 
APVAPSAAFS QNSTNAPRSV HAAVTPAAGK NSTGLPSTTM GHNPYFKDAS ASSTSTFDAR 

      1270       1280       1290       1300       1310       1320 
AAEMQRRIQR GLDEDEDDGW SDEDESNNRV AVDNKVEEAK IGHPDHARAP PVTAAPLPSV 

      1330       1340       1350       1360       1370       1380 
TPVPPAVPVP QANTSNEKSS PIPIAPIPPS VTQEPPVPLA PPLPAVDGFQ EPPIPSAPAI 

      1390       1400       1410       1420       1430       1440 
ATAVQKSGSS TPALAGGVLP PPPPLPTQQA STSEPIIAHV DNYNGAEKGT GAYGSDSDDD 

      1450       1460       1470       1480 
VLSIPESVGT DEEEEGAQPV STAGIPSIPP AGIPPPPPLP 

References and documentation are available.

Number of amino acids: 1480

Molecular weight: 160267.50

Theoretical pI: 5.17

Amino acid composition: 
Ala (A) 105	  7.1%
Arg (R)  40	  2.7%
Asn (N) 107	  7.2%
Asp (D)  65	  4.4%
Cys (C)   4	  0.3%
Gln (Q) 151	 10.2%
Glu (E)  80	  5.4%
Gly (G)  98	  6.6%
His (H)  11	  0.7%
Ile (I)  70	  4.7%
Leu (L)  90	  6.1%
Lys (K)  78	  5.3%
Met (M)  33	  2.2%
Phe (F)  47	  3.2%
Pro (P) 150	 10.1%
Ser (S) 148	 10.0%
Thr (T) 104	  7.0%
Trp (W)   4	  0.3%
Tyr (Y)  34	  2.3%
Val (V)  61	  4.1%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 145
Total number of positively charged residues (Arg + Lys): 118

Atomic composition:

Carbon      C	      6953
Hydrogen    H	     10962
Nitrogen    N	      1962
Oxygen      O	      2315
Sulfur      S	        37

Formula: C6953H10962N1962O2315S37
Total number of atoms: 22229

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    72910
Abs 0.1% (=1 g/l)   0.455, assuming all pairs of Cys residues form cystines


Ext. coefficient    72660
Abs 0.1% (=1 g/l)   0.453, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 62.82
This classifies the protein as unstable.



Aliphatic index: 61.21

Grand average of hydropathicity (GRAVY): -0.771