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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
RDMDDEESWI KEKKLLVGSE DYGRDLTGVQ NLRKKHKRLE GRLAEPEQAI QGVLDSGKKL

70 80 90 100 110 120
IDDNTIGREE IQQRPEQFVE HWKELKQLAA ARGQRLEESL EYQQFVANVE EEEAWINEKM

130 140 150 160 170 180
TLVASEDYGD TLAAIQGLLK KHEAFETDFT VHKDRVNDVC TNGQDLIKKN NHHEENISSK

190 200 210 220 230 240
MKGLNGKVSD LEKAAAQRKA KLDENSAFLQ FNWKADVVES WIGEKENSLK TDDYGRDLSS

250 260 270 280 290 300
VQTLLTKQET FDAGLQAFQQ EGIANITALK DQLLAAKHIQ SKAIEARHAS LMKRWTQLFA

310 320 330 340 350 360
NSATRKKKLL EAQSHFRKVE DLFLAFAKKA SAFNSWFENA EEDLTDPVRC NSLEEIKALR

370 380 390 400 410 420
EAHDAFRSSL SSAQADFNQL AELDRQIKSF RVASNPYTWF TMEALEETWR NLQKIIKERE

430 440 450 460 470
LELQKEQRRQ EENDKLRQEF AQHANAFHQW IQETRTYLLD GSCIGRRVGN SGISA


References and documentation are available.

Number of amino acids: 475 Molecular weight: 54713.21 Theoretical pI: 5.65
Amino acid composition: 
Ala (A) 46 9.7% Arg (R) 29 6.1% Asn (N) 24 5.1% Asp (D) 30 6.3% Cys (C) 3 0.6% Gln (Q) 34 7.2% Glu (E) 53 11.2% Gly (G) 21 4.4% His (H) 12 2.5% Ile (I) 21 4.4% Leu (L) 48 10.1% Lys (K) 42 8.8% Met (M) 5 1.1% Phe (F) 20 4.2% Pro (P) 4 0.8% Ser (S) 29 6.1% Thr (T) 20 4.2% Trp (W) 10 2.1% Tyr (Y) 6 1.3% Val (V) 18 3.8% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 83 Total number of positively charged residues (Arg + Lys): 71 Atomic composition: Carbon C 2398 Hydrogen H 3796 Nitrogen N 696 Oxygen O 755 Sulfur S 8 Formula: C2398H3796N696O755S8 Total number of atoms: 7653 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 64065 Abs 0.1% (=1 g/l) 1.171, assuming all pairs of Cys residues form cystines Ext. coefficient 63940 Abs 0.1% (=1 g/l) 1.169, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is R (Arg). The estimated half-life is: 1 hours (mammalian reticulocytes, in vitro). 2 min (yeast, in vivo). 2 min (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 42.38 This classifies the protein as unstable. Aliphatic index: 77.33 Grand average of hydropathicity (GRAVY): -0.814