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NiceZyme View of ENZYME: EC 1.1.1.262

Official Name
4-hydroxythreonine-4-phosphate dehydrogenase.
Alternative Name(s)
4-(phosphohydroxy)-L-threonine dehydrogenase.
L-threonine 4-phosphate dehydrogenase.
NAD(+)-dependent threonine 4-phosphate dehydrogenase.
Reaction catalysed
4-(phosphonooxy)-L-threonine + NAD(+) <=> (2S)-2-amino-3-oxo-4-phosphonooxybutanoate + NADH
Comment(s)
  • The product of the reaction undergoes decarboxylation to give 3-amino-2-oxopropyl phosphate.
  • In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.
Cross-references
BRENDA1.1.1.262
PUMA21.1.1.262
PRIAM enzyme-specific profiles1.1.1.262
KEGG Ligand Database for Enzyme Nomenclature1.1.1.262
IUBMB Enzyme Nomenclature1.1.1.262
IntEnz1.1.1.262
MEDLINEFind literature relating to 1.1.1.262
MetaCyc1.1.1.262
UniProtKB/Swiss-Prot
Q89NF3, PDXA1_BRAJA;  Q9I5U4, PDXA1_PSEAE;  Q92QZ0, PDXA1_RHIME;  
P58715, PDXA1_SALTI;  P58717, PDXA1_SALTY;  Q89MT9, PDXA2_BRAJA;  
Q9I1Q5, PDXA2_PSEAE;  Q92X16, PDXA2_RHIME;  P58716, PDXA2_SALTI;  
P58718, PDXA2_SALTY;  Q92TP3, PDXA3_RHIME;  Q8UGD4, PDXA_AGRT5;  
P58711, PDXA_ANASP;  O67019, PDXA_AQUAE;  A1K9J6, PDXA_AZOSB;  
Q5P7J0, PDXA_AZOSE;  Q9RC88, PDXA_BACHD;  Q89ZK3, PDXA_BACTN;  
P65680, PDXA_BRUME;  P65681, PDXA_BRUSU;  A4JHP8, PDXA_BURVG;  
A0RNS3, PDXA_CAMFF;  A8FMU4, PDXA_CAMJ8;  Q9PN58, PDXA_CAMJE;  
A1W0M2, PDXA_CAMJJ;  Q5HTM4, PDXA_CAMJR;  Q9A7N4, PDXA_CAUCR;  
Q7NQA9, PDXA_CHRVO;  A8ALP8, PDXA_CITK8;  A7FVM3, PDXA_CLOB1;  
A5I3X9, PDXA_CLOBH;  A7GFE5, PDXA_CLOBL;  A7ZHE5, PDXA_ECO24;  
P58713, PDXA_ECO57;  A7ZW04, PDXA_ECOHS;  Q8FL95, PDXA_ECOL6;  
B1IRC4, PDXA_ECOLC;  P19624, PDXA_ECOLI;  A4W6F8, PDXA_ENT38;  
Q47824, PDXA_ENTAG;  Q2N8X0, PDXA_ERYLH;  Q8RGR0, PDXA_FUSNN;  
Q39Q58, PDXA_GEOMG;  Q5FNS3, PDXA_GLUOX;  Q17ZN0, PDXA_HELAH;  
Q1CR24, PDXA_HELPH;  Q9ZJ28, PDXA_HELPJ;  O26103, PDXA_HELPY;  
A4G255, PDXA_HERAR;  A6SV12, PDXA_JANMA;  A1U6F9, PDXA_MARAV;  
Q0AQC2, PDXA_MARMM;  Q3V8A3, PDXA_METCA;  Q9JX42, PDXA_NEIMA;  
Q9K1F9, PDXA_NEIMB;  Q8CUU4, PDXA_OCEIH;  Q9CKG8, PDXA_PASMU;  
A4XZJ3, PDXA_PSEMY;  Q88QT5, PDXA_PSEPK;  Q88A45, PDXA_PSESM;  
A4VHI1, PDXA_PSEU5;  Q475Q2, PDXA_RALEJ;  P58714, PDXA_RALSO;  
Q984S6, PDXA_RHILO;  Q7UMZ2, PDXA_RHOBA;  Q3V7R9, PDXA_RHOPA;  
Q164G2, PDXA_ROSDO;  Q21MS9, PDXA_SACD2;  A9MQG1, PDXA_SALAR;  
A8G9P1, PDXA_SERP5;  Q8EB94, PDXA_SHEON;  Q326I1, PDXA_SHIBS;  
Q32K42, PDXA_SHIDS;  Q0T8E3, PDXA_SHIF8;  Q83SQ1, PDXA_SHIFL;  
Q3Z5V7, PDXA_SHISS;  Q1GI38, PDXA_SILST;  Q2NVX5, PDXA_SODGM;  
O85987, PDXA_SPHAR;  Q30S58, PDXA_SULDN;  Q8DHB4, PDXA_SYNEL;  
A0LIN6, PDXA_SYNFM;  Q2JSC8, PDXA_SYNJA;  Q2JKQ8, PDXA_SYNJB;  
A5GPX7, PDXA_SYNR3;  Q55982, PDXA_SYNY3;  Q9KUS1, PDXA_VIBCH;  
Q87ST5, PDXA_VIBPA;  Q8DED3, PDXA_VIBVU;  Q7MP85, PDXA_VIBVY;  
Q8D3I2, PDXA_WIGBR;  Q8PP24, PDXA_XANAC;  Q4UR40, PDXA_XANC8;  
Q8PCE2, PDXA_XANCP;  Q9PF39, PDXA_XYLFA;  Q87AJ1, PDXA_XYLFT;  
A1JJF5, PDXA_YERE8;  A7FMC0, PDXA_YERP3;  P58719, PDXA_YERPE;  
Q3V7Q4, PDXA_YERPS;  Q5NMX3, PDXA_ZYMMO;  

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