| Official Name |
|---|
| Nucleoside oxidase (H(2)O(2)-forming).
|
| Reaction catalysed |
|---|
| Adenosine + 2 O(2) <=> 9-riburonosyladenine + 2 H(2)O(2) |
| Cofactor(s) |
|---|
| FAD; Heme.
|
| Comment(s) |
|---|
- Other purine and pyrimidine nucleosides (as well as
2'-deoxynucleosides and arabinosides) are substrates, but ribose and
nucleotides are not substrates.
- The overall reaction takes place in two separate steps:
(1) Adenosine + O(2) = 5'-dehydroadenosine + H(2)O(2).
(2) 5'-dehydroadenosine + O(2) = 9-riburonosyladenine + H(2)O(2).
- The 5'-dehydro nucleoside is being released from the enzyme to serve
as substrate for the second reaction.
- Differs from EC 1.1.3.28 as it produces hydrogen peroxide rather than
water.
|
| Cross-references |
|---|
| BRENDA | 1.1.3.39 |
| PUMA2 | 1.1.3.39 |
| PRIAM enzyme-specific profiles | 1.1.3.39 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.3.39 |
| IUBMB Enzyme Nomenclature | 1.1.3.39 |
| IntEnz | 1.1.3.39 |
| MEDLINE | Find literature relating to 1.1.3.39 |
| MetaCyc | 1.1.3.39 |
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