ID   1.1.4.1
DE   Vitamin-K-epoxide reductase (warfarin-sensitive).
AN   Phylloquinone epoxide reductase.
AN   Vitamin K1 epoxide reductase.
CA   2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-
CA   epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-
CA   dithiothreitol.
CC   -!- In the reverse reaction, vitamin K 2,3-epoxide is reduced to vitamin
CC       K and possibly to vitamin K hydroquinone by 1,4-dithioerythritol,
CC       which is oxidized to a disulfide; some other dithiols and
CC       4-butanethiol can also act.
CC   -!- Inhibited strongly by warfarin (cf. EC 1.1.4.2).
DR   Q6B4J2, VKOR1_BOVIN;  Q9BQB6, VKOR1_HUMAN;  Q9CRC0, VKOR1_MOUSE;
DR   Q6TEK4, VKOR1_RAT  ;
//