ID 1.1.4.2 DE Vitamin-K-epoxide reductase (warfarin-insensitive). AN Vitamin K 2,3-epoxide reductase. CA 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized CA dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4- CA naphthoquinone + 1,4-dithiothreitol. CC -!- In the reverse reaction, vitamin K 2,3-epoxide is reduced to CC 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithioerythritol, which CC is oxidized to a disulfide. CC -!- Not inhibited by warfarin (cf. EC 1.1.4.1). //