| Official Name |
|---|
| Pyranose dehydrogenase (acceptor).
|
| Alternative Name(s) |
|---|
| PDH. |
| Pyranose dehydrogenase. |
| Pyranose-quinone oxidoreductase. |
| Quinone-dependent pyranose dehydrogenase. |
| Reaction catalysed |
|---|
- Pyranose + acceptor <=> 2-dehydropyranose + reduced acceptor
- Pyranose + acceptor <=> 3-dehydropyranose + reduced acceptor
- Pyranose + acceptor <=> 2,3-dehydropyranose + reduced acceptor
- A pyranoside + acceptor <=> a 3-dehydropyranoside + reduced acceptor
- A pyranoside + acceptor <=> a 3,4-dehydropyranoside + reduced acceptor
|
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- A number of aldoses and ketoses in pyranose form, as well as
glycosides, gluco-oligosaccharides, sucrose and lactose can act as a
donor.
- 1,4-benzoquinone or ferricenium ion (ferrocene oxidized by removal of
one electron) can serve as acceptor.
- Unlike EC 1.1.3.10, this fungal enzyme does not interact with O(2)
and exhibits extremely broad substrate tolerance with variable
regioselectivity (C-3, C-2 or C-3 + C-2 or C-3 + C-4) for
(di)oxidation of different sugars.
- D-glucose is exclusively or preferentially oxidized at C-3 (depending
on the enzyme source), but can also be oxidized at C-2 + C-3.
- The enzyme also acts on 1->4-alpha- and 1->4-beta-gluco-
oligosaccharides, non-reducing gluco-oligosaccharides and
L-arabinose, which are not substrates of EC 1.1.3.10.
- Sugars are oxidized in their pyranose but not in their furanose form.
|
| Cross-references |
|---|
| BRENDA | 1.1.99.29 |
| PUMA2 | 1.1.99.29 |
| PRIAM enzyme-specific profiles | 1.1.99.29 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.99.29 |
| IUBMB Enzyme Nomenclature | 1.1.99.29 |
| IntEnz | 1.1.99.29 |
| MEDLINE | Find literature relating to 1.1.99.29 |
| MetaCyc | 1.1.99.29 |
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