| Official Name |
|---|
| 2-oxo-acid reductase.
|
| Alternative Name(s) |
|---|
| (2R)-hydroxycarboxylate-viologen-oxidoreductase. |
| 2-oxoacid reductase. |
| HVOR. |
| Reaction catalysed |
|---|
| A (2R)-hydroxy-carboxylate + acceptor <=> a 2-oxo-carboxylate + reduced acceptor |
| Cofactor(s) |
|---|
| Iron-sulfur; Mononucleotide molybdenum (pyranopterin) cofactor.
|
| Comment(s) |
|---|
- Has broad substrate specificity, with 2-oxo-monocarboxylates and
2-oxo-dicarboxylates acting as substrates.
- Branching in a substrate at the C-3 position results in loss of
activity.
- The enzyme from Proteus sp. is inactivated by oxygen.
|
| Cross-references |
|---|
| BRENDA | 1.1.99.30 |
| PUMA2 | 1.1.99.30 |
| PRIAM enzyme-specific profiles | 1.1.99.30 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.99.30 |
| IUBMB Enzyme Nomenclature | 1.1.99.30 |
| IntEnz | 1.1.99.30 |
| MEDLINE | Find literature relating to 1.1.99.30 |
| MetaCyc | 1.1.99.30 |
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