| Official Name |
|---|
| Cholestanetriol 26-monooxygenase.
|
| Alternative Name(s) |
|---|
| 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase. |
| 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase. |
| Cholestanetriol 26-hydroxylase. |
| Cholesterol 27-hydroxylase. |
| Cytochrome P450 27A1'. |
| Sterol 26-hydroxylase. |
| Sterol 27-hydroxylase. |
| Vitamin D(3) 25-hydroxylase. |
| Reaction catalysed |
|---|
| 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O(2) <=> (25R)-5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP(+) + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Requires ferrodoxin.
- Acts on cholesterol, cholest-5-en-3-beta,7-alpha-diol, 7-alpha-
hydroxycholest-4-en-3-one, 5-beta-cholestane-3-alpha,7-alpha-diol as
well as 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol.
- With cholesterol as well as 26-hydroxycholesterol, 24-hydroxy- and
25-hydroxycholesterol are also formed.
- With prolonged treatment, 26-hydroxycholesterol is converted into the
corresponding 27-aldehyde and 27-oic acid.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | J10 |
| BRENDA | 1.14.13.15 |
| PUMA2 | 1.14.13.15 |
| PRIAM enzyme-specific profiles | 1.14.13.15 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.15 |
| IUBMB Enzyme Nomenclature | 1.14.13.15 |
| IntEnz | 1.14.13.15 |
| MEDLINE | Find literature relating to 1.14.13.15 |
| MetaCyc | 1.14.13.15 |
| UniProtKB/Swiss-Prot |
|
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