ID   1.14.13.50
DE   Pentachlorophenol monooxygenase.
AN   PCB 4-monooxygenase.
AN   PCB4MO.
AN   PCP hydroxylase.
AN   Pentachlorophenol 4-monooxygenase.
AN   Pentachlorophenol dechlorinase.
AN   Pentachlorophenol dehalogenase.
AN   Pentachlorophenol hydroxylase.
CA   (1) Pentachlorophenol + 2 NADPH + O(2) = 2,3,5,6-tetrachlorohydroquinone
CA   + 2 NADP(+) + chloride + H(2)O.
CA   (2) 2,3,5,6-tetrachlorophenol + NADPH + O(2) = 2,3,5,6-
CA   tetrachlorohydroquinone + NADP(+) + H(2)O.
CF   FAD.
CC   -!- The enzyme displaces a diverse range of substituents from the
CC       4-position of polyhalogenated phenols but requires that a halogen
CC       substituent be present at the 2-position.
CC   -!- The enzyme converts many polyhalogenated phenols into hydroquinones,
CC       and requires that a halogen substituent be present at C-2.
CC   -!- If C-4 carries a halogen substituent, reaction 1 is catalyzed, e.g.
CC       2,4,6-triiodophenol is oxidized to 2,6-diiodohydroquinone; if C-4 is
CC       unsubstituted, reaction 2 is catalyzed.
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