| Official Name |
|---|
| Methylsterol monooxygenase.
|
| Alternative Name(s) |
|---|
| 4-methylsterol oxidase. |
| Methylsterol hydroxylase. |
| Reaction catalysed |
|---|
- 4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) <=> 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O
- 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) <=> 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O
- 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) <=> 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O
|
| Comment(s) |
|---|
- Requires cytochrome b5.
- Also acts on 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol.
- The sterol can be based on cycloartenol as well as lanosterol.
- Formerly EC 1.14.99.16.
|
| Cross-references |
|---|
| BRENDA | 1.14.13.72 |
| PUMA2 | 1.14.13.72 |
| PRIAM enzyme-specific profiles | 1.14.13.72 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.13.72 |
| IUBMB Enzyme Nomenclature | 1.14.13.72 |
| IntEnz | 1.14.13.72 |
| MEDLINE | Find literature relating to 1.14.13.72 |
| MetaCyc | 1.14.13.72 |
| UniProtKB/Swiss-Prot |
| O59933, ERG25_CANAL; | Q5ZLL6, ERG25_CHICK; | Q7ZW77, ERG25_DANRE; |
| Q15800, ERG25_HUMAN; | Q4R4Q4, ERG25_MACFA; | Q9CRA4, ERG25_MOUSE; |
| Q6UGB2, ERG25_PIG; | Q5R574, ERG25_PONAB; | O35532, ERG25_RAT; |
| Q9UUH4, ERG25_SCHPO; | P53045, ERG25_YEAST; |
|
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