| Official Name |
|---|
| Tyrosine 3-monooxygenase.
|
| Alternative Name(s) |
|---|
| L-tyrosine hydroxylase. |
| Tyrosine 3-hydroxylase. |
| Tyrosine hydroxylase. |
| Reaction catalysed |
|---|
| L-tyrosine + tetrahydrobiopterin + O(2) <=> 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin |
| Cofactor(s) |
|---|
| Iron.
|
| Comment(s) |
|---|
- Activated by phosphorylation, catalyzed by EC 2.7.11.27.
- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
dihydrobiopterin, both spontaneously and by the action of
EC 4.2.1.96.
- The 6,7-dihydrobiopterin can be enzymically reduced back to
tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
more stable compound 7,8-dihydrobiopterin.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | G2 ; U4 |
| PROSITE | PDOC00316 |
| BRENDA | 1.14.16.2 |
| PUMA2 | 1.14.16.2 |
| PRIAM enzyme-specific profiles | 1.14.16.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.16.2 |
| IUBMB Enzyme Nomenclature | 1.14.16.2 |
| IntEnz | 1.14.16.2 |
| MEDLINE | Find literature relating to 1.14.16.2 |
| MetaCyc | 1.14.16.2 |
| UniProtKB/Swiss-Prot |
| O42091, TY3H_ANGAN; | P17289, TY3H_BOVIN; | P90986, TY3H_CAEEL; |
| Q76IQ3, TY3H_CANFA; | P18459, TY3H_DROME; | P07101, TY3H_HUMAN; |
| P24529, TY3H_MOUSE; | P11982, TY3H_PHASP; | P04177, TY3H_RAT; |
| O17446, TY3H_SCHMA; |
|
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