ID   1.14.16.2
DE   Tyrosine 3-monooxygenase.
AN   L-tyrosine hydroxylase.
AN   Tyrosine 3-hydroxylase.
AN   Tyrosine hydroxylase.
CA   L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine +
CA   4a-hydroxytetrahydrobiopterin.
CF   Iron.
CC   -!- Activated by phosphorylation, catalyzed by EC 2.7.11.27.
CC   -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
CC       dihydrobiopterin, both spontaneously and by the action of
CC       EC 4.2.1.96.
CC   -!- The 6,7-dihydrobiopterin can be enzymically reduced back to
CC       tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
CC       more stable compound 7,8-dihydrobiopterin.
PR   PROSITE; PDOC00316;
//