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NiceZyme View of ENZYME: EC 1.3.1.74

Official Name
2-alkenal reductase.
Alternative Name(s)
NAD(P)H-dependent alkenal/one oxidoreductase.
NADPH:2-alkenal alpha,beta-hydrogenase.
Reaction catalysed
n-alkanal + NAD(P)(+) <=> alk-2-enal + NAD(P)H
Comment(s)
  • Highly specific for 4-hydroxy-non-2-enal and non-2-enal.
  • 2-alkenals of shorter chain have lower affinities.
  • Exhibits high activities also for 2-alkenones such as but-3-en-2-one and pent-3-en-2-one.
  • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
  • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones.
Cross-references
BRENDA1.3.1.74
PUMA21.3.1.74
PRIAM enzyme-specific profiles1.3.1.74
KEGG Ligand Database for Enzyme Nomenclature1.3.1.74
IUBMB Enzyme Nomenclature1.3.1.74
IntEnz1.3.1.74
MEDLINEFind literature relating to 1.3.1.74
MetaCyc1.3.1.74
UniProtKB/Swiss-Prot
Q3SZJ4, LTB4D_BOVIN;  Q9EQZ5, LTB4D_CAVPO;  Q14914, LTB4D_HUMAN;  
Q91YR9, LTB4D_MOUSE;  Q29073, LTB4D_PIG;  Q28719, LTB4D_RABIT;  
P97584, LTB4D_RAT;  Q39172, P1_ARATH;  Q39173, P2_ARATH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
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