| Official Name |
|---|
| NAD(P)H oxidase.
|
| Alternative Name(s) |
|---|
| Dual oxidase. |
| ThOX. |
| THOX2. |
| Thyroid NADPH oxidase. |
| Thyroid oxidase. |
| Thyroid oxidase 2. |
| Reaction catalysed |
|---|
| NAD(P)H + O(2) <=> NAD(P)(+) + H(2)O(2) |
| Cofactor(s) |
|---|
| Calcium; FAD; Heme.
|
| Comment(s) |
|---|
- When calcium is present, this transmembrane glycoprotein generates
H(2)O(2) by transfering electrons from intracellular NAD(P)H to
extracellular molecular oxygen.
- The electron bridge within the enzyme contains one molecule of FAD
and probably two heme groups.
- This flavoprotein is expressed at the apical membrane of thyrocytes,
and provides H(2)O(2) for the thyroid peroxidase-catalyzed
biosynthesis of thyroid hormones.
|
| Cross-references |
|---|
| PROSITE | PDOC00394 |
| BRENDA | 1.6.3.1 |
| PUMA2 | 1.6.3.1 |
| PRIAM enzyme-specific profiles | 1.6.3.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.6.3.1 |
| IUBMB Enzyme Nomenclature | 1.6.3.1 |
| IntEnz | 1.6.3.1 |
| MEDLINE | Find literature relating to 1.6.3.1 |
| MetaCyc | 1.6.3.1 |
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