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NiceZyme View of ENZYME: EC 2.2.1.6

Official Name
Acetolactate synthase.
Alternative Name(s)
Acetohydroxy acid synthetase.
Acetohydroxyacid synthase.
Acetolactate pyruvate-lyase (carboxylating).
Acetolactic synthetase.
Alpha-acetohydroxy acid synthetase.
Alpha-acetohydroxyacid synthase.
Alpha-acetolactate synthase.
Alpha-acetolactate synthetase.
Reaction catalysed
2 pyruvate <=> 2-acetolactate + CO(2)
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
Cross-references
PROSITEPDOC00166
BRENDA2.2.1.6
PUMA22.2.1.6
PRIAM enzyme-specific profiles2.2.1.6
KEGG Ligand Database for Enzyme Nomenclature2.2.1.6
IUBMB Enzyme Nomenclature2.2.1.6
IntEnz2.2.1.6
MEDLINEFind literature relating to 2.2.1.6
MetaCyc2.2.1.6
UniProtKB/Swiss-Prot
P27818, ILVB1_BRANA;  Q41768, ILVB1_MAIZE;  Q6K2E8, ILVB1_ORYSJ;  
P09342, ILVB1_TOBAC;  P14874, ILVB2_BRANA;  Q41769, ILVB2_MAIZE;  
Q7XKQ8, ILVB2_ORYSJ;  P09114, ILVB2_TOBAC;  P27819, ILVB3_BRANA;  
P17597, ILVB_ARATH;  P37251, ILVB_BACSU;  P42463, ILVB_CORGL;  
Q5KPJ5, ILVB_CRYNE;  Q6SSJ3, ILVB_CRYNV;  O19929, ILVB_CYACA;  
P08142, ILVB_ECOLI;  Q09129, ILVB_ENTAE;  O78518, ILVB_GUITH;  
P27696, ILVB_KLEPN;  Q04524, ILVB_KLETE;  Q02137, ILVB_LACLA;  
O08353, ILVB_METAO;  Q57725, ILVB_METJA;  Q59498, ILVB_MYCAV;  
P0A623, ILVB_MYCBO;  O33112, ILVB_MYCLE;  P0A622, ILVB_MYCTU;  
P69683, ILVB_PORPU;  P69684, ILVB_PORUM;  Q1XDF6, ILVB_PORYE;  
P36620, ILVB_SCHPO;  P27868, ILVB_SPIPL;  Q7U5G1, ILVB_SYNPX;  
P07342, ILVB_YEAST;  P00892, ILVG_ECOLI;  P66947, ILVG_MYCBO;  
P66946, ILVG_MYCTU;  O67703, ILVH_AQUAE;  O28555, ILVH_ARCFU;  
P37252, ILVH_BACSU;  P57320, ILVH_BUCAI;  O85294, ILVH_BUCAP;  
Q89AP8, ILVH_BUCBP;  Q9TLY1, ILVH_CYACA;  P00894, ILVH_ECOLI;  
Q9MS98, ILVH_GALSU;  O78451, ILVH_GUITH;  P45260, ILVH_HAEIN;  
Q02140, ILVH_LACLA;  Q57625, ILVH_METJA;  O27492, ILVH_METTH;  
Q59499, ILVH_MYCAV;  P65162, ILVH_MYCBO;  O33113, ILVH_MYCLE;  
P65161, ILVH_MYCTU;  P51230, ILVH_PORPU;  Q1XDQ7, ILVH_PORYE;  
P21622, ILVH_SALTY;  Q55141, ILVH_SYNY3;  P57321, ILVI_BUCAI;  
O85293, ILVI_BUCAP;  Q89AP7, ILVI_BUCBP;  Q9RQ65, ILVI_BUCSC;  
P00893, ILVI_ECOLI;  P45261, ILVI_HAEIN;  P40811, ILVI_SALTY;  
P0ADG2, ILVM_ECOL6;  P0ADG1, ILVM_ECOLI;  P0ADG3, ILVM_SHIFL;  
P0ADG0, ILVN_ECO57;  P0ADF9, ILVN_ECOL6;  P0ADF8, ILVN_ECOLI;  
Q04789, ILVX_BACSU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-

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