| Official Name |
|---|
| Dihydrolipoyllysine-residue acetyltransferase.
|
| Alternative Name(s) |
|---|
| Acetyl-CoA:dihydrolipoamide S-acetyltransferase. |
| Dihydrolipoamide S-acetyltransferase. |
| Dihydrolipoate acetyltransferase. |
| Dihydrolipoic transacetylase. |
| Dihydrolipoyl acetyltransferase. |
| Lipoate acetyltransferase. |
| Lipoate transacetylase. |
| Lipoic acetyltransferase. |
| Lipoic acid acetyltransferase. |
| Lipoic transacetylase. |
| Lipoylacetyltransferase. |
| Thioltransacetylase A. |
| Transacetylase X. |
| Reaction catalysed |
|---|
| Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine <=> CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine |
| Comment(s) |
|---|
- A multimer (24-mer or 60-mer, depending on the source) of this enzyme
forms the core of the pyruvate dehydrogenase multienzyme complex,
and binds tightly both EC 1.2.4.1 and EC 1.8.1.4.
- The lipoyl group of this enzyme is reductively acetylated by
EC 1.2.4.1, and the only observed direction catalyzed by EC 2.3.1.12
is that where the acetyl group is passed to coenzyme A.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | F5 |
| BRENDA | 2.3.1.12 |
| PUMA2 | 2.3.1.12 |
| PRIAM enzyme-specific profiles | 2.3.1.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.12 |
| IUBMB Enzyme Nomenclature | 2.3.1.12 |
| IntEnz | 2.3.1.12 |
| MEDLINE | Find literature relating to 2.3.1.12 |
| MetaCyc | 2.3.1.12 |
| UniProtKB/Swiss-Prot |
| O31550, ACOC_BACSU; | Q59695, ACOC_PSEPU; | P27747, ACOC_RALEH; |
| P35489, ODP2_ACHLA; | P10802, ODP2_AZOVI; | P11961, ODP2_BACST; |
| P21883, ODP2_BACSU; | P11180, ODP2_BOVIN; | P57302, ODP2_BUCAI; |
| Q8K9T8, ODP2_BUCAP; | Q89AQ9, ODP2_BUCBP; | Q19749, ODP2_CAEEL; |
| P36413, ODP2_DICDI; | P06959, ODP2_ECOLI; | P45118, ODP2_HAEIN; |
| P10515, ODP2_HUMAN; | Q6ABX9, ODP2_LEIXX; | Q8BMF4, ODP2_MOUSE; |
| Q49110, ODP2_MYCCT; | P47514, ODP2_MYCGE; | P75392, ODP2_MYCPN; |
| P20285, ODP2_NEUCR; | Q59638, ODP2_PSEAE; | Q59098, ODP2_RALEH; |
| P08461, ODP2_RAT; | Q9R9N3, ODP2_RHIME; | Q1RJT3, ODP2_RICBR; |
| Q92HK7, ODP2_RICCN; | Q4ULG1, ODP2_RICFE; | Q9ZD20, ODP2_RICPR; |
| Q68WK6, ODP2_RICTY; | O59816, ODP2_SCHPO; | P81421, ODP2_SOLTU; |
| Q5HGY9, ODP2_STAAC; | P65635, ODP2_STAAM; | P65636, ODP2_STAAN; |
| Q6GHZ0, ODP2_STAAR; | Q6GAB9, ODP2_STAAS; | Q59821, ODP2_STAAU; |
| Q8NX76, ODP2_STAAW; | Q5HQ74, ODP2_STAEQ; | Q8CT13, ODP2_STAES; |
| P12695, ODP2_YEAST; | O66119, ODP2_ZYMMO; | P81420, ODP3_SOLTU; |
| Q0WQF7, OPD21_ARATH; | Q8RWN9, OPD22_ARATH; | Q5M729, OPD23_ARATH; |
|
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