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NiceZyme View of ENZYME: EC 2.6.1.52

Official Name
Phosphoserine transaminase.
Alternative Name(s)
3-phosphoserine aminotransferase.
3PHP transaminase.
Hydroxypyruvic phosphate--glutamic transaminase.
L-phosphoserine aminotransferase.
Phosphohydroxypyruvate transaminase.
Phosphohydroxypyruvic--glutamic transaminase.
Phosphoserine aminotransferase.
PSAT.
Reaction catalysed
  • O-phospho-L-serine + 2-oxoglutarate <=> 3-phosphonooxypyruvate + L-glutamate
  • 4-phosphonooxy-L-threonine + 2-oxoglutarate <=> (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Catalyzes the second step in the phosphorylated pathway of serine biosynthesis in Escherichia coli.
  • Also catalyzes the third step in the biosynthesis of the coenzyme pyridoxal 5'-phosphate in E.coli (using reaction 2 above).
  • In E.coli, pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate).
  • Pyridoxal phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis.
  • Non-phosphorylated forms of serine and threonine are not substrates.
Cross-references
Biochemical Pathways; map number(s)D6
PROSITEPDOC00514
BRENDA2.6.1.52
PUMA22.6.1.52
PRIAM enzyme-specific profiles2.6.1.52
KEGG Ligand Database for Enzyme Nomenclature2.6.1.52
IUBMB Enzyme Nomenclature2.6.1.52
IntEnz2.6.1.52
MEDLINEFind literature relating to 2.6.1.52
MetaCyc2.6.1.52
UniProtKB/Swiss-Prot
A1TSA3, SERC_ACIAC;  Q6F961, SERC_ACIAD;  Q96255, SERC_ARATH;  
Q5P7U7, SERC_AZOSE;  Q9RME2, SERC_BACAO;  Q734W9, SERC_BACC1;  
Q59196, SERC_BACCI;  Q81BC0, SERC_BACCR;  Q638W1, SERC_BACCZ;  
Q5LDN9, SERC_BACFN;  Q64UR4, SERC_BACFR;  Q9KDM4, SERC_BACHD;  
Q6HGI0, SERC_BACHK;  Q5WHT9, SERC_BACSK;  P80862, SERC_BACSU;  
Q8A8L4, SERC_BACTN;  A6L5A6, SERC_BACV8;  Q7VR40, SERC_BLOFL;  
Q2L2T1, SERC_BORA1;  Q7WGU2, SERC_BORBR;  Q7W5Z9, SERC_BORPA;  
Q7VZG4, SERC_BORPE;  P57397, SERC_BUCAI;  P81435, SERC_BUCAP;  
P59492, SERC_BUCBP;  Q1BY31, SERC_BURCA;  A0K5L8, SERC_BURCH;  
Q0BH96, SERC_BURCM;  Q39IG4, SERC_BURS3;  A4JCH1, SERC_BURVG;  
P91856, SERC_CAEEL;  A8FKB5, SERC_CAMJ8;  A7H543, SERC_CAMJD;  
Q9PIH3, SERC_CAMJE;  A1VY45, SERC_CAMJJ;  Q5HWE5, SERC_CAMJR;  
Q7NVP1, SERC_CHRVO;  A4QCG9, SERC_CORGB;  A9KCT6, SERC_COXBN;  
A9NC17, SERC_COXBR;  Q83E12, SERC_COXBU;  Q6ALW3, SERC_DESPS;  
Q55CQ6, SERC_DICDI;  A5EV80, SERC_DICNV;  Q9VAN0, SERC_DROME;  
Q8XEA7, SERC_ECO57;  Q8FJB7, SERC_ECOL6;  P23721, SERC_ECOLI;  
Q9X4H1, SERC_EDWIC;  Q6D400, SERC_ERWCT;  A5FH28, SERC_FLAJO;  
A6GXC2, SERC_FLAPJ;  Q5L296, SERC_GEOKA;  Q7VLP0, SERC_HAEDU;  
P44336, SERC_HAEIN;  Q0I322, SERC_HAES1;  Q9Y617, SERC_HUMAN;  
Q5QZ48, SERC_IDILO;  A8YW78, SERC_LACH4;  Q9CHW5, SERC_LACLA;  
A2RIS2, SERC_LACLM;  Q031D5, SERC_LACLS;  Q88ZU5, SERC_LACPL;  
Q5X5E7, SERC_LEGPA;  A5IBR0, SERC_LEGPC;  Q5ZVM2, SERC_LEGPH;  
Q5WWT0, SERC_LEGPL;  Q72VI2, SERC_LEPIC;  Q8F930, SERC_LEPIN;  
Q03W65, SERC_LEUMM;  Q926T3, SERC_LISIN;  Q71VT6, SERC_LISMF;  
Q8Y3L0, SERC_LISMO;  Q65S80, SERC_MANSM;  Q8TNI1, SERC_METAC;  
P52878, SERC_METBF;  Q8PT12, SERC_METMA;  Q99K85, SERC_MOUSE;  
A0QBI3, SERC_MYCA1;  P63515, SERC_MYCBO;  O33062, SERC_MYCLE;  
Q742L2, SERC_MYCPA;  A3Q635, SERC_MYCSJ;  A1ULN4, SERC_MYCSK;  
Q1B3G6, SERC_MYCSS;  P63514, SERC_MYCTU;  A1TF55, SERC_MYCVP;  
Q1D2L9, SERC_MYXXD;  Q5F7A0, SERC_NEIG1;  O34370, SERC_NEIMA;  
P57007, SERC_NEIMB;  A1KV48, SERC_NEIMF;  Q820S0, SERC_NITEU;  
A1SEM0, SERC_NOCSJ;  A6L9B7, SERC_PARD8;  P57881, SERC_PASMU;  
Q7N6D6, SERC_PHOLL;  Q6LPD9, SERC_PHOPR;  A1VR16, SERC_POLNA;  
Q12CL3, SERC_POLSJ;  Q7MV30, SERC_PORGI;  Q9HZ66, SERC_PSEAE;  
Q3ILA3, SERC_PSEHT;  Q88M07, SERC_PSEPK;  Q885T5, SERC_PSESM;  
Q9RI02, SERC_PSEST;  P10658, SERC_RABIT;  Q8Y0Z0, SERC_RALSO;  
Q7UQL3, SERC_RHOBA;  Q21Y51, SERC_RHOFD;  Q0S6R3, SERC_RHOSR;  
Q57R24, SERC_SALCH;  P62676, SERC_SALGL;  P62677, SERC_SALTI;  
P55900, SERC_SALTY;  Q10349, SERC_SCHPO;  Q8EEH2, SERC_SHEON;  
Q83LP3, SERC_SHIFL;  P52877, SERC_SPIOL;  Q8E3Y3, SERC_STRA3;  
Q8DSV3, SERC_STRMU;  A4W0D4, SERC_STRS2;  A3CPJ2, SERC_STRSV;  
A4VU42, SERC_STRSY;  Q5LYP0, SERC_STRT1;  Q5M3A4, SERC_STRT2;  
Q03JH6, SERC_STRTD;  A0LK14, SERC_SYNFM;  Q3SK88, SERC_THIDA;  
Q9KSU7, SERC_VIBCH;  Q5E6F2, SERC_VIBF1;  Q87QA3, SERC_VIBPA;  
Q8D900, SERC_VIBVU;  Q7MLH6, SERC_VIBVY;  Q8D268, SERC_WIGBR;  
Q8PLY7, SERC_XANAC;  Q3BUZ3, SERC_XANC5;  Q4UTC9, SERC_XANC8;  
Q8PA97, SERC_XANCP;  Q2P354, SERC_XANOM;  Q5H079, SERC_XANOR;  
Q8RLW0, SERC_XENNE;  Q9PB19, SERC_XYLFA;  Q87BU0, SERC_XYLFT;  
P33330, SERC_YEAST;  P19689, SERC_YERE8;  Q8ZGB4, SERC_YERPE;  
Q66CI9, SERC_YERPS;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-

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