| Official Name |
|---|
| [Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
|
| Alternative Name(s) |
|---|
| 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase. |
| 3-hydroxy-3-methylglutaryl-CoA reductase kinase. |
| [Hydroxymethylglutaryl-CoA reductase (NADPH(2))] kinase. |
| AMP-activated protein kinase. |
| AMPK. |
| Beta-hydroxy-beta-methylglutaryl-CoA reductase kinase. |
| HMG-CoA reductase kinase. |
| Hydroxymethylglutaryl coenzyme A reductase kinase. |
| Hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating). |
| Hydroxymethylglutaryl-CoA reductase kinase. |
| Reductase kinase. |
| Reaction catalysed |
|---|
| ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] <=> ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate |
| Comment(s) |
|---|
- Activated by AMP.
- EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme
protein.
- Histones can also act as acceptors.
- Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79.
- Thr-172 within the catalytic subunit (alpha-subunit) is the major
site phosphorylated by the AMP-activated protein kinase kinase.
- GTP can act instead of ATP.
- Formerly EC 2.7.1.109.
|
| Cross-references |
|---|
| BRENDA | 2.7.11.31 |
| PUMA2 | 2.7.11.31 |
| PRIAM enzyme-specific profiles | 2.7.11.31 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.31 |
| IUBMB Enzyme Nomenclature | 2.7.11.31 |
| IntEnz | 2.7.11.31 |
| MEDLINE | Find literature relating to 2.7.11.31 |
| MetaCyc | 2.7.11.31 |
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