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NiceZyme View of ENZYME: EC 4.1.2.13

Official Name
Fructose-bisphosphate aldolase.
Alternative Name(s)
Aldolase.
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase.
Fructose-1,6-bisphosphate triosephosphate-lyase.
Reaction catalysed
D-fructose 1,6-bisphosphate <=> glycerone phosphate + D-glyceraldehyde 3-phosphate
Cofactor(s)
Zinc.
Comment(s)
  • Also acts on (3S,4R)-ketose 1-phosphates.
  • The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
  • Formerly EC 4.1.2.7.
Cross-references
Biochemical Pathways; map number(s)C5 ; C6 ; U9
PROSITEPDOC00143 ; PDOC00523
BRENDA4.1.2.13
PUMA24.1.2.13
PRIAM enzyme-specific profiles4.1.2.13
KEGG Ligand Database for Enzyme Nomenclature4.1.2.13
IUBMB Enzyme Nomenclature4.1.2.13
IntEnz4.1.2.13
MEDLINEFind literature relating to 4.1.2.13
MetaCyc4.1.2.13
UniProtKB/Swiss-Prot
P04075, ALDOA_HUMAN;  P05064, ALDOA_MOUSE;  A5A6I5, ALDOA_PANTR;  
Q5NVR5, ALDOA_PONAB;  P00883, ALDOA_RABIT;  P05065, ALDOA_RAT;  
Q3T0S5, ALDOB_BOVIN;  P07341, ALDOB_CHICK;  Q8JH71, ALDOB_DANRE;  
P05062, ALDOB_HUMAN;  Q91Y97, ALDOB_MOUSE;  Q5RFA6, ALDOB_PONAB;  
P79226, ALDOB_RABIT;  P00884, ALDOB_RAT;  P52210, ALDOB_SHEEP;  
P53447, ALDOB_SPAAU;  P53448, ALDOC_CARAU;  P53449, ALDOC_CHICK;  
Q8JH70, ALDOC_DANRE;  P09972, ALDOC_HUMAN;  Q9GKW3, ALDOC_MACFA;  
P05063, ALDOC_MOUSE;  Q5R1X4, ALDOC_PANTR;  P09117, ALDOC_RAT;  
Q9YG90, ALF1_AERPE;  P54216, ALF1_CAEEL;  Q9PKH8, ALF1_CHLMU;  
Q9Z8Q7, ALF1_CHLPN;  O84217, ALF1_CHLTR;  Q97TN4, ALF1_CLOAB;  
A6LXU8, ALF1_CLOB8;  P0A992, ALF1_ECOL6;  P0A991, ALF1_ECOLI;  
Q8RGH3, ALF1_FUSNN;  P53445, ALF1_LAMJA;  Q8ELI2, ALF1_OCEIH;  
P46256, ALF1_PEA;  P60053, ALF1_PORGI;  Q9V2I6, ALF1_PYRAB;  
P58314, ALF1_PYRFU;  O57840, ALF1_PYRHO;  Q8J308, ALF1_PYRKO;  
Q59100, ALF1_RALEH;  P27995, ALF1_RHOSH;  A7X6Y6, ALF1_STAA1;  
A6U4Y6, ALF1_STAA2;  Q2FDQ4, ALF1_STAA3;  Q2FV17, ALF1_STAA8;  
A5IW31, ALF1_STAA9;  Q2YWF3, ALF1_STAAB;  Q5HCU6, ALF1_STAAC;  
A6QK93, ALF1_STAAE;  P67472, ALF1_STAAM;  P99117, ALF1_STAAN;  
Q6GDJ7, ALF1_STAAR;  Q6G670, ALF1_STAAS;  A8Z3K5, ALF1_STAAT;  
Q8NUM5, ALF1_STAAW;  Q07159, ALF1_STACA;  Q5HL21, ALF1_STAEQ;  
Q8CMY5, ALF1_STAES;  Q4L9B6, ALF1_STAHJ;  P74309, ALF1_SYNY3;  
P58315, ALF1_THETE;  Q73QV3, ALF1_TREDE;  Q8PHB5, ALF1_XANAC;  
Q8P5Z7, ALF1_XANCP;  Q9PF52, ALF1_XYLFA;  Q87AI0, ALF1_XYLFT;  
P46563, ALF2_CAEEL;  P53446, ALF2_LAMJA;  P46257, ALF2_PEA;  
P49577, ALF2_PLABA;  Q59101, ALF2_RALEH;  P50923, ALF2_RHOCA;  
P29271, ALF2_RHOSH;  Q5HE75, ALF2_STAAC;  P67477, ALF2_STAAM;  
P99075, ALF2_STAAN;  Q6GEV0, ALF2_STAAR;  Q6G7I5, ALF2_STAAS;  
P67478, ALF2_STAAW;  Q5HM97, ALF2_STAEQ;  Q8CNI3, ALF2_STAES;  
Q55664, ALF2_SYNY3;  Q9SJU4, ALFC1_ARATH;  Q01516, ALFC1_PEA;  
Q944G9, ALFC2_ARATH;  Q01517, ALFC2_PEA;  Q9ZU52, ALFC3_ARATH;  
Q42690, ALFC_CHLRE;  Q40677, ALFC_ORYSJ;  P84722, ALFC_PINST;  
P16096, ALFC_SPIOL;  P83155, ALF_ANASL;  P22197, ALF_ARATH;  
Q9HGY9, ALF_ASPOR;  P94453, ALF_BACST;  P13243, ALF_BACSU;  
O51401, ALF_BORBU;  P57526, ALF_BUCAI;  Q8K9B2, ALF_BUCAP;  
Q89AB6, ALF_BUCBP;  Q0PAS0, ALF_CAMJE;  A1VYV7, ALF_CAMJJ;  
Q9URB4, ALF_CANAL;  O65735, ALF_CICAR;  P19537, ALF_CORGL;  
Q86A67, ALF_DICDI;  P07764, ALF_DROME;  Q9GP32, ALF_ECHMU;  
P0AB72, ALF_ECO57;  P0AB71, ALF_ECOLI;  O52402, ALF_EDWIC;  
P44429, ALF_HAEIN;  Q9ZMQ6, ALF_HELPJ;  P56109, ALF_HELPY;  
Q9C2U0, ALF_KLULA;  P91759, ALF_LYMST;  P08440, ALF_MAIZE;  
P67476, ALF_MYCBO;  P47269, ALF_MYCGE;  O69600, ALF_MYCLE;  
P75089, ALF_MYCPN;  P67475, ALF_MYCTU;  P53444, ALF_NEUCR;  
Q9XDP3, ALF_NOSCO;  P17784, ALF_ORYSJ;  Q8J0N6, ALF_PARBR;  
Q7KQL9, ALF_PLAF7;  P14223, ALF_PLAFA;  Q9I5Y1, ALF_PSEAE;  
O87796, ALF_PSEST;  P58336, ALF_RHIME;  P53442, ALF_SCHMA;  
P36580, ALF_SCHPO;  P0AB73, ALF_SHIFL;  P56888, ALF_SINMW;  
P29356, ALF_SPIOL;  Q9X8R6, ALF_STRCO;  Q9ZEM7, ALF_STRGB;  
P68905, ALF_STRP1;  Q8K5W5, ALF_STRP3;  Q5XA12, ALF_STRP6;  
P68906, ALF_STRP8;  P0A4S1, ALF_STRPN;  P0A4S2, ALF_STRR6;  
Q703I2, ALF_THECA;  O83668, ALF_TREPA;  P07752, ALF_TRYBB;  
Q9PPP3, ALF_UREPA;  Q56815, ALF_XANFL;  P14540, ALF_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
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