| Official Name |
|---|
| 2-hydroxypropyl-CoM lyase.
|
| Alternative Name(s) |
|---|
| Coenzyme M-epoxyalkane ligase. |
| EaCoMT. |
| Reaction catalysed |
|---|
- (R)-2-hydroxypropyl-CoM <=> (R)-1,2-epoxypropane + HS-CoM
- (S)-2-hydroxypropyl-CoM <=> (S)-1,2-epoxypropane + HS-CoM
|
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Acts on both enantiomers of chiral epoxyalkanes to form the
corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts.
- The enzyme will function with some other thiols (e.g.,
2-sulfanylethanol) as the nucleophile.
- Uses short-chain epoxyalkanes from C(2) (epoxyethane) to C(6) (1,2-
epoxyhexane).
- This enzyme forms component I of a four-component enzyme system
(comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II),
EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is
involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
- Formerly EC 4.2.99.19.
|
| Cross-references |
|---|
| BRENDA | 4.4.1.23 |
| PUMA2 | 4.4.1.23 |
| PRIAM enzyme-specific profiles | 4.4.1.23 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.4.1.23 |
| IUBMB Enzyme Nomenclature | 4.4.1.23 |
| IntEnz | 4.4.1.23 |
| MEDLINE | Find literature relating to 4.4.1.23 |
| MetaCyc | 4.4.1.23 |
| UniProtKB/Swiss-Prot |
|
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