| Official Name |
|---|
| Sirohydrochlorin ferrochelatase.
|
| Reaction catalysed |
|---|
| Siroheme + 2 H(+) <=> sirohydrochlorin + Fe(2+) |
| Comment(s) |
|---|
- This enzyme catalyzes the third of three steps leading to the
formation of siroheme from uroporphyrinogen III.
- The first step involves the donation of two S-adenosyl-L-methionine-
derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to
form precorrin-2 (EC 2.1.1.107) and the second step involves an
NAD(+)-dependent dehydrogenation to form sirohydrochlorin from
precorrin-2 (EC 1.3.1.76).
- In Saccharomyces cerevisiae, the last two steps are carried out by a
single bifunctional enzyme, Met8p.
- In some bacteria, steps 1-3 are catalyzed by a single multifunctional
protein called CysG, whereas in Bacillus megaterium, three separate
enzymes carry out each of the steps, with SirB being responsible for
the above reaction.
|
| Cross-references |
|---|
| BRENDA | 4.99.1.4 |
| PUMA2 | 4.99.1.4 |
| PRIAM enzyme-specific profiles | 4.99.1.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.99.1.4 |
| IUBMB Enzyme Nomenclature | 4.99.1.4 |
| IntEnz | 4.99.1.4 |
| MEDLINE | Find literature relating to 4.99.1.4 |
| MetaCyc | 4.99.1.4 |
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