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| PROSITE documentation PDOC00004 |
There has been a number of studies relative to the specificity of cAMP- and cGMP-dependent protein kinases [1,2,3]. Both types of kinases appear to share a preference for the phosphorylation of serine or threonine residues found close to at least two consecutive N-terminal basic residues. It is important to note that there are quite a number of exceptions to this rule.
June 1988 / First entry.
PROSITE method (with tools and information) covered by this documentation:
| CAMP_PHOSPHO_SITE, PS00004; cAMP- and cGMP-dependent protein kinase phosphorylation site (PATTERN with a high probability of occurrence!) | ||
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| 1 | Authors | Fremisco J.R., Glass D.B., Krebs E.G. |
| Source | J. Biol. Chem. 255:4240-4245(1980). |
| 2 | Authors | Glass D.B., Smith S.B. |
| Title | Phosphorylation by cyclic GMP-dependent protein kinase of a synthetic peptide corresponding to the autophosphorylation site in the enzyme. | |
| Source | J. Biol. Chem. 258:14797-14803(1983). | |
| PubMed ID | 6317673 |
| 3 | Authors | Glass D.B., el-Maghrabi M.R., Pilkis S.J. |
| Title | Synthetic peptides corresponding to the site phosphorylated in 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as substrates of cyclic nucleotide-dependent protein kinases. | |
| Source | J. Biol. Chem. 261:2987-2993(1986). | |
| PubMed ID | 3005275 |
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