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PROSITE documentation PDOC00315

Uricase signature

Description:

Uricase (EC 1.7.3.3) (urate oxidase) [1] is the peroxisomal enzyme responsible for the degradation of urate into allantoin. Some species, like primates and birds, have lost the gene for uricase and are therefore unable to degrade urate.

Uricase is a protein of 300 to 400 amino acids, its sequence is well conserved and we have used, as a signature pattern, a highly conserved region located in the central part of the sequence.

Last update:

July 1999 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

URICASE, PS00366; Uricase signature  (PATTERN)
Consensus pattern: [LV] - x - [LV] - [LIV] - K - [STV] - [ST] - x - [SN] - x - F - x(2) - [FY] - x(4) - [FY] - x(2) - L - x(5) - R
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00366
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00366
• Scan Swiss-Prot/TrEMBL entries against PS00366
• view ligand binding statistics
Matching PDB structures: 1J2G 1R4S 1R4U 1R51 ... [ALL]

Reference:

1 AuthorsMotojima K., Kanaya S., Goto S.
TitleCloning and sequence analysis of cDNA for rat liver uricase.
SourceJ. Biol. Chem. 263:16677-16681(1988).
PubMed ID3182808

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