Histidinol dehydrogenase (EC 1.1.1.23) (HDH) catalyzes the terminal step in
the biosynthesis of histidine in bacteria, fungi, and plants, the four-electron oxidation of L-histidinol to histidine.
In bacteria HDH is a single chain polypeptide; in fungi it is the C-terminal
domain of a multifunctional enzyme which catalyzes three different steps of
histidine biosynthesis; and in plants it is expressed as nuclear encoded
protein precursor which is exported to the chloroplast [1].
As a signature pattern we selected a highly conserved region located in the
central part of HDH. This region does not correspond to the part of the enzyme
that, in most, but not all HDH sequences contains a cysteine residue which, in
Salmonella typhimurium, has been said [2] to be important for the catalytic
activity of the enzyme.
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