Dihydroorotate dehydrogenase (EC 1.3.3.1) (DHOdehase) catalyzes the fourth
step in the de novo biosynthesis of pyrimidine, the conversion of
dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein.
In bacteria (gene pyrD), DHOdease is located on the inner side of the
cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene
URA1), it is a cytosolic protein while in other eukaryotes it is found in the
mitochondria [1].
The sequence of DHOdease is rather well conserved and we have developed two
signature patterns specific to this enzyme. The first corresponds to a region
in the N-terminal section of the enzyme while the second is located in the C-terminal section and seems to be part of the FAD-binding domain.
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