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| PROSITE documentation PDOC00815 |
Pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) is a FMN flavoprotein involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. The sequences of the enzyme from bacterial (genes pdxH or fprA) [1] and fungal (gene PDX3) [2] sources show that this protein has been highly conserved throughout evolution.
PdxH is evolutionary related [3] to one of the enzymes in the phenazine biosynthesis protein pathway, phzD (also known as phzG).
As a signature pattern, we selected a highly conserved region located in the C-terminal part of these enzymes.
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
| PYRIDOX_OXIDASE, PS01064; Pyridoxamine 5'-phosphate oxidase signature (PATTERN) | ||||||
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| Matching PDB structures: 1CI0 1DNL 1G76 1G77 ... [ALL] |
| 1 | Authors | Lam H.-M., Winkler M.E. |
| Title | Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations. | |
| Source | J. Bacteriol. 174:6033-6045(1992). | |
| PubMed ID | 1356963 |
| 2 | Authors | Loubbardi A., Marcireau C., Karst F., Guilloton M. |
| Title | Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase. | |
| Source | J. Bacteriol. 177:1817-1823(1995). | |
| PubMed ID | 7896706 |
| 3 | Authors | Pierson L.S. III, Gaffney T., Lam S., Gong F. |
| Title | Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium. Pseudomonas aureofaciens 30-84. | |
| Source | FEMS Microbiol. Lett. 134:299-307(1995). | |
| PubMed ID | 8586283 |
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