Species code:	BRUME
Taxonomy:	Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella (TaxID: 29459) [NEWT/ NCBI]
Description:	Brucellosis is a major infectious disease for both human and animals. Several Brucella species (B.abortus, B. melitensis and B.suis) have been isolated from many different animals. All three Brucella species cause a severe human disease characterized in its acute phase by undulant fever and in its chronic phase by damage of different organs. When the infection is localized to the brain or the heart, it can result in a fatal meningitidis or fatal endocarditis, respectively. Brucellosis is a major problem in the Mediterranean region and parts of Asia, Africa and Latin America. Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and undulant fever in humans. The disease is transmitted to human by consumption of nonpasteurized milk and milk products or by direct contact with infected animals and carcasses. Although Brucellae contain a large set of flagellar genes, they display a species-specific gene inactivation and consequently are nonmotile.
Properties:	Presence of flagella: No Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of BRUME entries in the UniProt Knowledgebase: 3178 (545 in UniProtKB/Swiss-Prot + 2633 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome I EMBL accession number AE008917 (circular; 2,117,144 bp) (download entry) (download Genome Reviews). • Chromosome II EMBL accession number AE008918 (circular; 1,177,787 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=20020109; PubMed=11756688; [ NCBI , EBI , Israel , Japan ] DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. ; "The genome sequence of the facultative intracellular pathogen Brucella melitensis."; Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Brucella&GLspecies=melitensis&GLstrain=16M Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid224914%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Bmel_16M Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Brucella_melitensis.html PATRIC: http://patric.vbi.vt.edu/genome/overview.php?genomeId=10 PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p180_Bru_melit RhizoDB: http://xbase.bham.ac.uk/rhizodb/genome.pl?id=967 TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=ntbm01  EBI Proteome Analysis page

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