ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Proteomics tools Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Search for

ProtScale

ProtScale [Reference / Documentation] allows you to compute and represent the profile produced by any amino acid scale on a selected protein.

An amino acid scale is defined by a numerical value assigned to each type of amino acid. The most frequently used scales are the hydrophobicity or hydrophilicity scales and the secondary structure conformational parameters scales, but many other scales exist which are based on different chemical and physical properties of the amino acids. This program provides 56 predefined scales entered from the literature.

Enter a UniProtKB/Swiss-Prot or UniProtKB/TrEMBL accession number (AC) (e.g. P05130) or a sequence identifier (ID) (e.g. KPC1_DROME):

Or you can paste your own sequence in the box below:

Please choose an amino acid scale from the following list. To display information about a scale (author, reference, amino acid scale values) you can click on its name. 

 Molecular weight                         Number of codon(s)
 Bulkiness                                Polarity / Zimmerman
 Polarity / Grantham                      Refractivity
 Recognition factors                      Hphob. / Eisenberg et al.
 Hphob. OMH / Sweet et al.                Hphob. / Hopp & Woods
 Hphob. / Kyte & Doolittle                Hphob. / Manavalan et al.
 Hphob. / Abraham & Leo                   Hphob. / Black
 Hphob. / Bull & Breese                   Hphob. / Fauchere et al.
 Hphob. / Guy                             Hphob. / Janin
 Hphob. / Miyazawa et al.                 Hphob. / Rao & Argos
 Hphob. / Roseman                         Hphob. / Wolfenden et al.
 Hphob. / Welling & al                    Hphob. HPLC / Wilson & al
 Hphob. HPLC / Parker & al                Hphob. HPLC pH3.4 / Cowan
 Hphob. HPLC pH7.5 / Cowan                Hphob. / Rf mobility
 HPLC / HFBA retention                    HPLC / TFA retention
 Transmembrane tendency                   HPLC / retention pH 2.1
 HPLC / retention pH 7.4                  % buried residues
 % accessible residues                    Hphob. / Chothia
 Hphob. / Rose & al                       Ratio hetero end/side
 Average area buried                      Average flexibility
 alpha-helix / Chou & Fasman              beta-sheet / Chou & Fasman
 beta-turn / Chou & Fasman                alpha-helix / Deleage & Roux
 beta-sheet / Deleage & Roux              beta-turn / Deleage & Roux
 Coil / Deleage & Roux                    alpha-helix / Levitt
 beta-sheet / Levitt                      beta-turn / Levitt
 Total beta-strand                        Antiparallel beta-strand
 Parallel beta-strand                     A.A. composition
 A.A. comp. in Swiss-Prot                 Relative mutability
Window size:
Relative weight of the window edges compared to the window center (in %):
Weight variation model (if the relative weight at the edges is < 100%): linear exponential
Do you want to normalize the scale from 0 to 1? yes no

If you need more information about how to set these parameters, please click here.