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UniProtKB/Swiss-Prot entry A0KKK9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRD_AERHH
Primary accession number A0KKK9
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on December 12, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 18)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase
Synonyms EC 1.3.3.1
Dihydroorotate oxidase
DHOdehase
DHODase
DHOD
Gene name
Name: pyrD
OrderedLocusNames: AHA_2287
From
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240) [TaxID: 380703] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales; Aeromonadaceae; Aeromonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.00621-06; PubMed=16980456 [NCBI, ExPASy, EBI, Israel, Japan]
Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
"Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
J. Bacteriol. 188:8272-8282(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000462; ABK37752.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_856810.1; -.
3D structure databases
ModBase A0KKK9.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00225; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005719; DHO_DHase_2.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01036; pyrD_sub2; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.
BLOCKS A0KKK9.
Genome annotation databases
GeneID 4488940; -.
GenomeReviews CP000462_GR; AHA_2287.
KEGG aha:AHA_2287; -.
TIGR AHA_2287; -.
Other
ProtoNet A0KKK9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Flavoprotein; FMN; Membrane; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   336  336     Dihydroorotate dehydrogenase. PRO_1000024147
ACT_SITE   175   175        Nucleophile (By similarity). 
Sequence information
Length: 336 AA [This is the length of the unprocessed precursor] Molecular weight: 36360 Da [This is the MW of the unprocessed precursor] CRC64: C2D036246386BE8D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLYPLARHFL FKLNPEQAHD LSIKYLPRLL GTPLDCFFRH SLPKRPVTVM GLSFANPVGL 

        70         80         90        100        110        120 
AAGLDKDGEC IDAFGAMGFG FIEVGTVTPR PQSGNDKPRL FRVIPAEGII NRMGFNNKGV 

       130        140        150        160        170        180 
DHLVAQVKKA KYQGVIGINI GKNKDTPIEQ GKDDYLICMD KVYDQAGYIA VNISSPNTPG 

       190        200        210        220        230        240 
LRSLQYGDAL DELLAALKVR QQELAAQYKK YVPLAVKIAP DLTPDEINQV AASLIKNGID 

       250        260        270        280        290        300 
GVIATNTTLE RDMIYDMPHA AEAGGLSGRP LQHKSTEVIR QLAKALDGAL PIIGVGGIDS 

       310        320        330 
AMAAREKLAA GASLVQIYSG FIYKGPDLVK EIVTHI
A0KKK9 in FASTA format

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