FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH₃ + NADP⁺ = guanosine 5'-phosphate + NADPH.
SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

CP000539; ABM43448.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_987524.1; -.

3D structure databases

ModBase

A1WB23.

Ontologies

GO:0003920;	Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163;	Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01511; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF00478; IMPDH; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036500; GMP_red_Firmic; 1.

TIGRFAMs

TIGR01306; GMP_reduct_2; 1.

PROSITE

PS00487; IMP_DH_GMP_RED; 1.

BLOCKS

A1WB23.

Genome annotation databases

GeneID

4670813; -.

GenomeReviews

CP000539_GR; Ajs_3326.

KEGG

ajs:Ajs_3326; -.

CMR

A1WB23; Ajs_3326.

Other

ProtoNet

A1WB23.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 325`	`325`	`GMP reductase.`	`PRO_0000294270`
`NP_BIND`	`202 225`	`24`	`NADP (Potential).`
`ACT_SITE`	`173 173`		`Thioimidate intermediate (By similarity).`

Sequence information

Length: 325 AA [This is the length of the unprocessed precursor]

Molecular weight: 35771 Da [This is the MW of the unprocessed precursor]

CRC64: 93B64E736912B803 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEIFDYDNIL LLPRKCRVES RSECDTSVEL GERRFRLPVV PANMKTVVDE KICTWLAQNG 

        70         80         90        100        110        120 
YFYVMHRFDL DNVQFVKDMH AQGCFASISL GVKQPDYDTV DRFVAEGICP EYITIDIAHG 

       130        140        150        160        170        180 
HADSVKNMIT YLKAKIPAAF VIAGNVGTPE AVIDLENWGA DATKVGIGPG KVCITKLKTG 

       190        200        210        220        230        240 
FGTGGWQLSA LKWCARVATK PIIADGGIRS HGDIAKSVRF GATMVMVGSL FAGHEESPGK 

       250        260        270        280        290        300 
TVEVDGELYK EYYGSASDFN KGEYKHVEGK RILEPIKGKL ADTLTEMEQD IQSSISYSGG 

       310        320 
KKLMDIRKVN YVILGGDNAG EHLLM

A1WB23 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools