NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.01845-07; PubMed=18065534 [NCBI, ExPASy, EBI, Israel, Japan]
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.;
"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b).";
J. Bacteriol. 190:1495-1496(2008).

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
PATHWAY: Context: Aromatic amino acids biosynthesis .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000569; ABN74229.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001053834.1; -.

3D structure databases

ModBase

A3N1E3.

Ontologies

GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

BLOCKS

A3N1E3.

Genome annotation databases

GeneID

4849556; -.

GenomeReviews

CP000569_GR; APL_1139.

KEGG

apl:APL_1139; -.

CMR

A3N1E3; APL_1139.

Other

ProtoNet

A3N1E3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 274`	`274`	`Shikimate dehydrogenase.`	`PRO_0000325094`
`NP_BIND`	`126 130`	`5`	`NADP (By similarity).`

Sequence information

Length: 274 AA [This is the length of the unprocessed precursor]

Molecular weight: 30546 Da [This is the MW of the unprocessed precursor]

CRC64: F409E2980F5292D2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNQYAVWGNP IAQSKSPRIH QLFGEQTGKS ISYVAKLGNE LNFENELMQF FAEGAKGANI 

        70         80         90        100        110        120 
TAPFKERAFS LADEYSESCL LAEACNTLKR LDDGRLYADN TDGFGLCSDL ERLGWLKPHQ 

       130        140        150        160        170        180 
RVLILGAGGA TKGVLFPLLK AKQQITIYNR TLEKAVRLAE KFAKYGKIRT ASLEQIAEQQ 

       190        200        210        220        230        240 
FDLIINATSL GLQGKYVPVA AHLLKSAAVY DMQYAPDMQT PFLNYARECG AVRYQDGLGM 

       250        260        270 
LVGQAGFAFK LWENEFPNVE KVLKQLKNEM ENAK

A3N1E3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools