NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L.;
"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449.";
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate (By similarity).
CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD⁺ + H₂O = N-succinyl-L-glutamate + NADH.
PATHWAY: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000644; ABO89257.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001141005.1; -.

3D structure databases

ModBase

A4SK35.

Ontologies

GO:0019544;	Biological process: arginine catabolic process to glutamate (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01174; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR017649; SuccinylGlu_semiald_DH_AstD.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

A4SK35.

Genome annotation databases

GeneID

4994861; -.

GenomeReviews

CP000644_GR; ASA_1136.

KEGG

asa:ASA_1136; -.

CMR

A4SK35; ASA_1136.

Other

ProtoNet

A4SK35.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Arginine metabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 489`	`489`	`N-succinylglutamate 5-semialdehyde dehydrogenase.`	`PRO_1000065746`
`NP_BIND`	`223 228`	`6`	`NAD (By similarity).`
`ACT_SITE`	`246 246`		`By similarity.`
`ACT_SITE`	`280 280`		`By similarity.`

Sequence information

Length: 489 AA [This is the length of the unprocessed precursor]

Molecular weight: 51986 Da [This is the MW of the unprocessed precursor]

CRC64: 1C0701C1BF730184 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSHLVQLIDG QWLAGEGKPF ESMDPAKNEV IWQGGAASAS QVDAAVKAAR AAFYHWSDLA 

        70         80         90        100        110        120 
LEDRLAIVRR YADLLGEHKE ALALTIARET GKPLWETRTE VAAMQGKIAI SIRAHDERTG 

       130        140        150        160        170        180 
TVENPMPGAK AFVRHKPHGV VAVFGPYNFP GHLPNGHIVP ALIAGNTVVF KPSELTPMVA 

       190        200        210        220        230        240 
EAMLKIWQEA GLPKGVLNLV QGEVETGKAL AGNPDIDGLF FTGSSRTGHF LHQQFAGQPG 

       250        260        270        280        290        300 
KILALEMGGN NPLIVKDVSD VDGAVHAIVQ SAFITSGQRC TCSRRLFVER GARGDALVKR 

       310        320        330        340        350        360 
LVEVVGQIKV GLYDAADQPF MGAMISEKAA LGMVAAQANL QQLGGESLLT LKHLEAGTGF 

       370        380        390        400        410        420 
VSPGIIDVTA IGALPDEEYF GPLLQLIRYD DFDAAIDQGN ATSFGLSAGL LGDNEADWQH 

       430        440        450        460        470        480 
FFKRIRAGIV NWNKPITGAS SAAPFGGIGA SGNHRASAYY AADYCAYPVA SVEDSKAAMP 


DQLSPGLTF

A4SK35 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools