NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L.;
"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449.";
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
PATHWAY: Context: Aromatic amino acids biosynthesis .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000644; ABO92071.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001143819.1; -.

3D structure databases

ModBase

A4ST49.

Ontologies

GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

BLOCKS

A4ST49.

Genome annotation databases

GeneID

4997265; -.

GenomeReviews

CP000644_GR; ASA_4132.

KEGG

asa:ASA_4132; -.

CMR

A4ST49; ASA_4132.

Other

ProtoNet

A4ST49.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 273`	`273`	`Shikimate dehydrogenase.`	`PRO_1000021254`
`NP_BIND`	`126 130`	`5`	`NADP (By similarity).`

Sequence information

Length: 273 AA [This is the length of the unprocessed precursor]

Molecular weight: 29223 Da [This is the MW of the unprocessed precursor]

CRC64: D6B2C39817E9152B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDRYLVFGHP VRHSKSPFIH TLFARQTQQE LEYGLAEPAV DEFATTLRAF FAQGGKGCNV 

        70         80         90        100        110        120 
TVPFKEQAFA LVDSLSPRAK RAGAVNTIKL TDDGVLLGDN TDGAGLVADL KSHGVALAGS 

       130        140        150        160        170        180 
RILLLGAGGA ARGALAPLLA EHPTELVIAN RTHAKAQQLA AEFHDLGVVT ALTYEQLGGT 

       190        200        210        220        230        240 
FDLIINSTSA SLQGELPPLS PALIHADIAI YDMMYGSMDT PFISWAKQYG ARQAMDGLGM 

       250        260        270 
LVEQAAEAFT VWRGIRPGTK QVLRELKRNL GTL

A4ST49 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools