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UniProtKB/Swiss-Prot entry A8FFW6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ILVC_BACP2
Primary accession number A8FFW6
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on November 13, 2007 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 10)
Name and origin of the protein
Protein name Ketol-acid reductoisomerase
Synonyms EC 1.1.1.86
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene name
Name: ilvC
OrderedLocusNames: BPUM_2470
From
Bacillus pumilus (strain SAFR-032) [TaxID: 315750] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pone.0000928; PubMed=17895969 [NCBI, ExPASy, EBI, Israel, Japan]
Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M.;
"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.";
PLoS ONE 2:E928-E928(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000813; ABV63133.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001487693.1; -.
3D structure databases
ModBase A8FFW6.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004455; Molecular function: ketol-acid reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0009097; Biological process: isoleucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009099; Biological process: valine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00435; -; 1.
PBIL [Tree]
InterPro IPR013023; AcH_isomrdctse.
IPR000506; AcH_isomrdctse_C.
IPR013116; IlvN.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR21371; AcH_isomrdctse; 1.
Pfam PF01450; IlvC; 1.
PF07991; IlvN; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00465; ilvC; 1.
ProtoNet A8FFW6.
Genome annotation databases
GeneID 5621739; -.
GenomeReviews CP000813_GR; BPUM_2470.
KEGG bpu:BPUM_2470; -.
CMR A8FFW6; BPUM_2470.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   342  342     Ketol-acid reductoisomerase. PRO_1000060226
ACT_SITE   107   107        Potential. 
Sequence information
Length: 342 AA [This is the length of the unprocessed precursor] Molecular weight: 37507 Da [This is the MW of the unprocessed precursor] CRC64: 6F09EA8918463B77 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVKVYYNGDI QENVLNGQKV AIIGYGSQGH AHALNLKESG VDVIVGVRKG GSYTKAQEDG 

        70         80         90        100        110        120 
HQVFTVKEAA AQADVLMVLL PDEQQKKVYD EEIKDQLEAG NSLVFAHGFN VHFHQIVPPS 

       130        140        150        160        170        180 
DVDVYLVAPK GPGHLVRRTY EQGAGVPALF AIYQDVSGQA KDKALAYAKA IGGARAGVLE 

       190        200        210        220        230        240 
TTFKEETETD LFGEQAVLCG GLTSLVKAGF ETLTEAGYQP ELAYFECLHE LKLIVDLMYE 

       250        260        270        280        290        300 
EGLEGMRYSI SDTAQWGDFV SGPRVVDANV KESMKAVLTD IQNGTFAKEW IVENQVNRPR 

       310        320        330        340 
FNAINANENE HQIEVVGRKL REMMPFVKQG KKKEAVSVGA EN
A8FFW6 in FASTA format

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