ID   ASTD_SERP5              Reviewed;         490 AA.
AC   A8GFQ3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-NOV-2008, entry version 10.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=Spro_2842;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000826; ABV41943.1; -; Genomic_DNA.
DR   RefSeq; YP_001479071.1; -.
DR   GeneID; 5603120; -.
DR   GenomeReviews; CP000826_GR; Spro_2842.
DR   KEGG; spe:Spro_2842; -.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:InterPro.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    490       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_1000065763.
FT   NP_BIND     223    228       NAD (By similarity).
FT   ACT_SITE    246    246       By similarity.
FT   ACT_SITE    280    280       By similarity.
SQ   SEQUENCE   490 AA;  52392 MW;  8DB57EC365C40843 CRC64;
     MSHPALFING AWQQGRGAEF SKTDPVDNQP LWQANAADGS DVAAACEAAR AAFPAWARTP
     FEQREQLVKR FAALLEEHKS HLAATISRET SKPRWETLTE VQAMIGKVAI SLQAYQVRTG
     VSQTAMADGA SVLRHRPHGV LAVFGPYNFP GHLPNGHIVP ALLAGNTVVF KPSELTPQTA
     EETLKLWQQA GLPDGVINMV QGGRETGEAL AASTDIDGLL FTGSAGTGYH LHRQLAGQPE
     KILALEMGGN NALIVDQIED CDAAVNLAIQ SAFISAGQRC TCSRRILVKR GSEGDAFIER
     LVQVASALRI GRWDAEPQPF MGGVISSAAA EKMLAAQHHL LSLGGKALLT MQRLESGSAL
     LSPGIIDVTG VRDVPDEEYF GPLTTIIRYN DFDEAVRIAN QTRYGLSVGL VSPQRERFDH
     LLLEARAGIV NWNKPLTGAS SAAPFGGVGA SGNHRPSAYY AADYCAWPMA SLESESLTLP
     ASLSPGLSFN
//