NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.;
"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571.";
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
PATHWAY: Context: Aromatic amino acids biosynthesis .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP009384; BAF86001.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001522919.1; -.

3D structure databases

ModBase

A8IFY6.

Ontologies

GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

BLOCKS

A8IFY6.

Genome annotation databases

GeneID

5690391; -.

GenomeReviews

AP009384_GR; AZC_0003.

CMR

A8IFY6; AZC_0003.

Other

ProtoNet

A8IFY6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 281`	`281`	`Shikimate dehydrogenase.`	`PRO_0000325101`
`NP_BIND`	`127 131`	`5`	`NADP (By similarity).`

Sequence information

Length: 281 AA [This is the length of the unprocessed precursor]

Molecular weight: 29633 Da [This is the MW of the unprocessed precursor]

CRC64: B671580DF7A5C194 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKRVAIFGHP VIHSRSPLVH GYWLKQHGIA GDYVRHDVAP DEAEAFFARF AEQGYAGGNV 

        70         80         90        100        110        120 
TIPHKEVAFN ALAEADPVAR ALGVANTLWL EDGRLFGANT DAPGFLSNLD VTAPGWDANP 

       130        140        150        160        170        180 
RVALVLGAGG ASRAVLYGFL QRGFDKVLLA NRTLARAEAL AAHFGPRVVP IGWDGVSASL 

       190        200        210        220        230        240 
KEAQVVANTT SLGMKGQPPL DLDLSVLADD AVVADVVYVP LETPLLKAAK ARGLRTVDGL 

       250        260        270        280 
GMLLHQAVPG FARWFGVTPQ VDAGLRDLIV ADLAAKGQLG A

A8IFY6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools