ID   AROE_AZOC5              Reviewed;         281 AA.
AC   A8IFY6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-NOV-2008, entry version 12.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=AZC_0003;
OS   Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Azorhizobium.
OX   NCBI_TaxID=438753;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T.,
RA   Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B.,
RA   Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M.,
RA   Oyaizu H.;
RT   "Complete genome sequence of the nitrogen-fixing bacterium
RT   Azorhizobium caulinodans ORS571.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AP009384; BAF86001.1; -; Genomic_DNA.
DR   RefSeq; YP_001522919.1; -.
DR   GeneID; 5690391; -.
DR   GenomeReviews; AP009384_GR; AZC_0003.
DR   KEGG; azc:AZC_0003; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   InterPro; IPR011342; Quinate/shikimate_5-DHase.
DR   InterPro; IPR013708; Shikimate_DHase-bd_N.
DR   InterPro; IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    281       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325101.
FT   NP_BIND     127    131       NADP (By similarity).
FT   ACT_SITE     65     65       Proton acceptor (Potential).
SQ   SEQUENCE   281 AA;  29633 MW;  B671580DF7A5C194 CRC64;
     MKRVAIFGHP VIHSRSPLVH GYWLKQHGIA GDYVRHDVAP DEAEAFFARF AEQGYAGGNV
     TIPHKEVAFN ALAEADPVAR ALGVANTLWL EDGRLFGANT DAPGFLSNLD VTAPGWDANP
     RVALVLGAGG ASRAVLYGFL QRGFDKVLLA NRTLARAEAL AAHFGPRVVP IGWDGVSASL
     KEAQVVANTT SLGMKGQPPL DLDLSVLADD AVVADVVYVP LETPLLKAAK ARGLRTVDGL
     GMLLHQAVPG FARWFGVTPQ VDAGLRDLIV ADLAAKGQLG A
//