[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate (By similarity).
CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD⁺ + H₂O = N-succinyl-L-glutamate + NADH.
PATHWAY: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

CP000880; ABX21565.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001570707.1; -.

3D structure databases

ModBase

A9MFG0.

Ontologies

GO:0043824;	Molecular function: succinylglutamate-semialdehyde dehydrogenase activity (inferred from electronic annotation from EC).
GO:0019544;	Biological process: arginine catabolic process to glutamate (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01174; -; 1.
PBIL [Tree]

InterPro

IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR017649; SuccinylGlu_semiald_DH_AstD.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

A9MFG0.

Genome annotation databases

GeneID

5763416; -.

GenomeReviews

CP000880_GR; SARI_01674.

CMR

A9MFG0; SARI_01674.

Other

ProtoNet

A9MFG0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Arginine metabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 492`	`492`	`N-succinylglutamate 5-semialdehyde dehydrogenase.`	`PRO_1000085404`
`NP_BIND`	`220 225`	`6`	`NAD (By similarity).`
`ACT_SITE`	`243 243`		`By similarity.`
`ACT_SITE`	`277 277`		`By similarity.`

Sequence information

Length: 492 AA [This is the length of the unprocessed precursor]

Molecular weight: 53001 Da [This is the MW of the unprocessed precursor]

CRC64: 98C7F8A8930D5A00 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTLWINGDWI TGQGERRSKT NPVSAEILWQ GNDADTAQVA GACEAARAAF PCWARQPFAA 

        70         80         90        100        110        120 
RQAIVEKFAV LLEEHKAELT AVIARETGKP RWEAATEVTA MINKIAISIK AYHARTGEQT 

       130        140        150        160        170        180 
SELADGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLIFKPS ELTPWTGETV 

       190        200        210        220        230        240 
IKLWERAGLP AGVLNLVQGG RETGHALSLL DDLDGLLFTG SASTGYQLHR QLSGQPKKIL 

       250        260        270        280        290        300 
ALEMGGNNPL IIEDAEDIDA AVHLTLQSAF ITAGQRCTCA RRLLVKQGVQ GDAFLARLVD 

       310        320        330        340        350        360 
VAGRLQPGRW DDDPQPFIGG LISAQAAQHV IEAWHQREAL GGRTLLAPRK VKEGTSLLTP 

       370        380        390        400        410        420 
GIIELTGVTD VPDEEVFGPL LSVWRYDHFD EAIHLANSTR FGLSCGLVST DRAQFEQLLL 

       430        440        450        460        470        480 
EARAGIVNWN KPLTGAASTS PFGGVGASGN HRPSAWYAAD YCAWPMATLE SPELTLPATL 

       490 
SPGLDFSRRE AV

A9MFG0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools