[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Seshadri R., Samuel J.E.; "Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."; Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
PATHWAY: Context: Aromatic amino acids biosynthesis .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000890; ABX77620.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001597801.1; -.

3D structure databases

ModBase

A9NBH0.

Ontologies

GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

TIGRFAMs

TIGR00507; aroE; 1.

BLOCKS

A9NBH0.

Genome annotation databases

GeneID

5793247; -.

GenomeReviews

CP000890_GR; aroE.

CMR

A9NBH0; COXBURSA331_A2191.

Other

ProtoNet

A9NBH0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 272`	`272`	`Shikimate dehydrogenase.`	`PRO_1000078118`
`NP_BIND`	`127 131`	`5`	`NADP (By similarity).`

Sequence information

Length: 272 AA [This is the length of the unprocessed precursor]

Molecular weight: 29794 Da [This is the MW of the unprocessed precursor]

CRC64: F1DA0DAB51DADB73 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDKYAVIGNP VEHSLSPVIF QAFEKQTNHS FDYLKIKAPV NGFAAAVKKF HDEGGKGANI 

        70         80         90        100        110        120 
TLPFKEEAYQ LADKRSQEAN EAHVASALQF REDGTIYAVN YDGLGLVQDL TRNHNITLTQ 

       130        140        150        160        170        180 
KSILIVGAGG ATRGILGPLL NAAPEKIVIV NRTPSKAHAL AKIFHLRGEI QGGGFDELEP 

       190        200        210        220        230        240 
MRYDVIIHAT SLGHQGKFPP LPDGLIGSQS CCYDLSYGKI ASPFLQWAKD QGAKYNFDGL 

       250        260        270 
GMLVEHNAAV FYLWFGIYPD TNPVIEMLQA HL

A9NBH0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools