[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Axillary bud; Walton E.F., Podivinsky E., Wu R.M., Reynolds P.H.S., Young L.W.; Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

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Cross-references

Sequence databases

EMBL

U92287; AAC14482.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

O04016.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 278`	`278`		`Pyrroline-5-carboxylate reductase.`	`PRO_0000187322`

Sequence information

Length: 278 AA [This is the length of the unprocessed precursor]

Molecular weight: 29004 Da [This is the MW of the unprocessed precursor]

CRC64: 198B6E934F190236 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAAAFVPIP TDTYKLGFIG AGKMAESIAR GVVKSGVLPA SRIRTAHLGS ARREAFESFG 

        70         80         90        100        110        120 
VKVLDRNDQV VEDSDVIIFS VKPQIVKEVV LQLRPLLSEK QLLVSIVAGV KLKELEDWAG 

       130        140        150        160        170        180 
HSRFIRVMPN TPAAVGEAAS VMSLGATATG EDGELITKLF GAIGKIWKAD EKLFDAVTGL 

       190        200        210        220        230        240 
SGSGPAYIFL AIEALADGGV AAGLPRELAL GLASQTVLGA ASMVARGGKH PGQLKDDVAS 

       250        260        270 
AGGTTIAGIH ELEKGGFRGT LMNAVVSATK RSQEIFKR

O04016 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools