NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 50394;
DOI=10.1038/387493a0; PubMed=9168110 [NCBI, ExPASy, EBI, Israel, Japan]
Lang B.F., Burger G., O'Kelly C.J., Cedergren R., Golding G.B., Lemieux C., Sankoff D., Turmel M., Gray M.W.;
"An ancestral mitochondrial DNA resembling a eubacterial genome in miniature.";
Nature 387:493-497(1997).

Comments

CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
COFACTOR: Binds 1 4Fe-4S cluster (Potential).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the complex I 20 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF007261; AAD11899.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S78166; S78166.

RefSeq

NP_044784.1; -.

3D structure databases

ModBase

O21272.

Family and domain databases

InterPro

IPR006138; NADH_DHase_20kDa_su.
IPR014406; NiFe_hyd_3_ssu/Q_oxred_NuoB.
IPR006137; OxRdtase_q6.
Graphical view of domain structure.

PANTHER

PTHR11995:SF2; NADH_DH_20kDa; 1.
PTHR11995; NiFe_hyd_3_ssu/Q_oxred_NuoB; 1.

Pfam

PF01058; Oxidored_q6; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01957; nuoB_fam; 1.

PROSITE

PS01150; COMPLEX1_20K; 1.

BLOCKS

O21272.

Genome annotation databases

GeneID

801085; -.

Other

ProtoNet

O21272.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 182`	`182`	`NADH-ubiquinone oxidoreductase 20 kDa subunit.`	`PRO_0000118740`
`METAL`	`57 57`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`58 58`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`122 122`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`152 152`		`Iron-sulfur (4Fe-4S) (Potential).`

Sequence information

Length: 182 AA [This is the length of the unprocessed precursor]

Molecular weight: 20925 Da [This is the MW of the unprocessed precursor]

CRC64: 0B4663AB65303D48 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEERCFRLGI KTNYKKEIFM ILNNKQNKTE FIVSKMDELV NWARKGSLWP MTFGLACCAV 

        70         80         90        100        110        120 
EMMHSAASRY DLDRFGIIFR PSPRQSDVMI VAGTLTNKMA PALRKVYDQM SEPRWVVSMG 

       130        140        150        160        170        180 
SCANGGGYYH YSYSVVRGCD RIVPVDIYVP GCPPTAEALL YGLLQLQKKI KRSRKTLYWL 


QK

O21272 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools