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UniProtKB/Swiss-Prot entry O27090

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G3P_METTH
Primary accession number O27090
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 65)
Name and origin of the protein
Protein name Glyceraldehyde-3-phosphate dehydrogenase
Synonyms GAPDH
EC 1.2.1.59
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene name
Name: gap
OrderedLocusNames: MTH_1009
From
Methanobacterium thermoautotrophicum [TaxID: 187420] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Delta H;
PubMed=9371463 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J., Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
"Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.";
J. Bacteriol. 179:7135-7155(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000666; AAB85505.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E69001; E69001.
RefSeq NP_276144.1; -.
3D structure databases
HSSP P10618; 1CF2. [HSSP ENTRY / PDB]
SMR O27090; 1-337.
ModBase O27090.
Enzyme and pathway databases
BioCyc MTHE187420:MTH1009-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00559; -; 1.
PBIL [Tree]
InterPro IPR000173; GlycerAld_3-P_DHase.
IPR006436; Glyceraldehyde-3-P_DHase_2_arc.
Graphical view of domain structure.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
ProDom PD004105; DapB; 1.
PD007761; GAPDH_like; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01546; GAPDH-II_archae; 1.
PROSITE PS00071; GAPDH; 1.
BLOCKS O27090.
Genome annotation databases
GeneID 1471417; -.
GenomeReviews AE000666_GR; MTH_1009.
KEGG mth:MTH1009; -.
NMPDR fig|187420.1.peg.999; -.
Phylogenomic databases
HOGENOM O27090; -.
Genome annotation databases
CMR O27090; MTH_1009.
Other
ProtoNet O27090.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   337  337     Glyceraldehyde-3-phosphate dehydrogenase. PRO_0000145726
NP_BIND   11    12  2     NAD (By similarity). 
REGION   139   141  3     Glyceraldehyde 3-phosphate binding (By similarity). 
REGION   194   195  2     Glyceraldehyde 3-phosphate binding (By similarity). 
ACT_SITE   140   140        Nucleophile (By similarity). 
BINDING   110   110        NAD; via amide nitrogen (By similarity). 
BINDING   168   168        NAD (By similarity). 
BINDING   301   301        NAD; via carbonyl oxygen (By similarity). 
Sequence information
Length: 337 AA [This is the length of the unprocessed precursor] Molecular weight: 36836 Da [This is the MW of the unprocessed precursor] CRC64: 730FEDB11CF9BAA3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MISVAINGYG TIGKRVADAV AAQDDMKVAG VSKTKPDFEA RVAIEKGYDL YVSIPEREKL 

        70         80         90        100        110        120 
FGEAGIPVSG TVEDMLEEAD IVVDATPEGI GAKNLEMYRE KGIKAIFQGG EKHDAIGLSF 

       130        140        150        160        170        180 
NSFANYDESL GADYTRVVSC NTTGLCRTLK PIDDLCGIKK VRAVMVRRGA DPVQVKKGPI 

       190        200        210        220        230        240 
NAIVPNPPTV PSHHGPDLKT VMKGVNIHTV ALLVPTTLMH QHNIMVELED PVEADEIKAR 

       250        260        270        280        290        300 
LDETTRVMLV RASEGLASTA EIMEYAKELG RSRNDLFEIP VWEESINVVD GELFYMQAVH 

       310        320        330 
QESDAVPESV DAIRALLELE EDNMKSIMKT NRAMGIL
O27090 in FASTA format

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