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UniProtKB/Swiss-Prot entry O30027

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_ARCFU
Primary accession number O30027
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 59)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: AF_0212
From
Archaeoglobus fulgidus [TaxID: 2234] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
DOI=10.1038/37052; PubMed=9389475 [NCBI, ExPASy, EBI, Israel, Japan]
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.";
Nature 390:364-370(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000782; AAB91021.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D69276; D69276.
RefSeq NP_069050.1; -.
3D structure databases
HSSP P06988; 1K75. [HSSP ENTRY / PDB]
ModBase O30027.
Enzyme and pathway databases
BioCyc AFUL224325:AF_0212-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002197; HTH_Fis.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
PR01590; HTHFIS.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS O30027.
Genome annotation databases
GeneID 1483423; -.
GenomeReviews AE000782_GR; AF_0212.
KEGG afu:AF0212; -.
NMPDR fig|224325.1.peg.209; -.
TIGR AF_0212; -.
Phylogenomic databases
HOGENOM O30027; -.
Other
ProtoNet O30027.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   404  404     Histidinol dehydrogenase. PRO_0000135890
ACT_SITE   300   300        Proton acceptor (By similarity). 
ACT_SITE   301   301        Proton acceptor (By similarity). 
METAL   244   244        Zinc (By similarity). 
METAL   247   247        Zinc (By similarity). 
METAL   334   334        Zinc (By similarity). 
METAL   393   393        Zinc (By similarity). 
BINDING   114   114        NAD (By similarity). 
BINDING   176   176        NAD (By similarity). 
BINDING   199   199        NAD (By similarity). 
BINDING   222   222        Substrate (By similarity). 
BINDING   244   244        Substrate (By similarity). 
BINDING   247   247        Substrate (By similarity). 
BINDING   301   301        Substrate (By similarity). 
BINDING   334   334        Substrate (By similarity). 
BINDING   388   388        Substrate (By similarity). 
BINDING   393   393        Substrate (By similarity). 
Sequence information
Length: 404 AA [This is the length of the unprocessed precursor] Molecular weight: 44152 Da [This is the MW of the unprocessed precursor] CRC64: 344264D010F20966 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEEILRLRRS VSIDDYIEKV KPIVEAVKRE GDKAVIRFTR DLDGVELDSL RVTEDEFEKA 

        70         80         90        100        110        120 
YDAVDDGLID ALEVAKENIY RFHYVTSVER DMKVEFEDCV MGKIYTPIEK VGAYIPGGRA 

       130        140        150        160        170        180 
SYPSTALMIG VPAKIAGVEK LVACTPPNKD GKVNPLTLVA LDIAEFDEVY KAGGAQAIAA 

       190        200        210        220        230        240 
MAYGTETVEK VYKIVGPGNI YVTAAKLLVA KDVAIDMPAG PSEILVIADE TANADFIACD 

       250        260        270        280        290        300 
CLAQLEHDPM AVAVVLTTSR KVADEVEKKV KSEGDFSNFA VFVVEDLAEA FEISNEFAPE 

       310        320        330        340        350        360 
HLTVAVKNPE EWLGKVRNAG SVFLGNFSPV AAGDYASGTN HVLPTAGYAK IYGGLSVESF 

       370        380        390        400 
LKHFTFQMLS EESMRRIGGD VVKIAEAEGL RWHAESVRKR LEKI
O30027 in FASTA format

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