ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O35532


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name ERG25_RAT
Primary accession number O35532
Secondary accession numbers None
Integrated into Swiss-Prot on February 22, 2003
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 52)
Name and origin of the protein
Protein name C-4 methylsterol oxidase
Synonyms EC 1.14.13.72
Methylsterol monooxygenase
Neuropep 1
RANP-1
Gene name
Name: Sc4mol
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
DOI=10.1016/S0306-4522(97)00112-7; PubMed=9284352 [NCBI, ExPASy, EBI, Israel, Japan]
Uwabe K., Gahara Y., Yamada H., Miyake T., Kitamura T.;
"Identification and characterization of a novel gene (neurorep 1) expressed in nerve cells and up-regulated after axotomy.";
Neuroscience 80:501-509(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D50559; BAA23329.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC063155; AAH63155.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_543162.1; -.
UniGene Rn.7167
3D structure databases
ModBase O35532.
Organism-specific databases
RGD 620281; Sc4mol.
Gene expression databases
ArrayExpress O35532; -.
GermOnline ENSRNOG00000032297; Rattus norvegicus.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR006088; Sterol_desatur.
Graphical view of domain structure.
Pfam PF01598; Sterol_desat; 1.
Pfam graphical view of domain structure.
BLOCKS O35532.
Genome annotation databases
Ensembl ENSRNOG00000032297; Rattus norvegicus. [Contig view]
GeneID 140910; -.
KEGG rno:140910; -.
Phylogenomic databases
HOVERGEN O35532; -.
Other
ProtoNet O35532.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Iron; Lipid synthesis; Membrane; NAD; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   293  293     C-4 methylsterol oxidase. PRO_0000117036
TRANSMEM   55    75  21     Potential. 
TRANSMEM   100   120  21     Potential. 
TRANSMEM   199   219  21     Potential. 
MOTIF   157   161  5     Histidine box-1. 
MOTIF   170   174  5     Histidine box-2. 
MOTIF   249   255  7     Histidine box-3. 
Sequence information
Length: 293 AA [This is the length of the unprocessed precursor] Molecular weight: 34964 Da [This is the MW of the unprocessed precursor] CRC64: FEE8C22FDC5F38D7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAMNKSVGLF SSASLAVDYV DSLLPENPLQ EPFKNAWVYM LDNYTKFQIA TWGSLIVHET 

        70         80         90        100        110        120 
IYFLFSLPGF LFQFIPFMRK YKIQKDKPET FEGQWKCLKG ILFNHFFIQL PLICGTYYFT 

       130        140        150        160        170        180 
EFFNIPYDWE RMPRWYFTLA RCLGCAVIED TWHYFLHRLL HHKRIYKYIH KVHHEFQAPF 

       190        200        210        220        230        240 
GIEAEYAHPL ETLILGTGFF IGIVLLCDHV ILLWAWVTMR LLETIDVHSG YDIPLNPLNY 

       250        260        270        280        290 
IPFYTGARHH DFHHMNFIGN YASTFTWWDR IFGTDVQYHA YTEKMKKLGK KSE 

O35532 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!