ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O35936


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name LX15B_MOUSE
Primary accession number O35936
Secondary accession numbers None
Integrated into Swiss-Prot on January 11, 2001
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 77)
Name and origin of the protein
Protein name Arachidonate 15-lipoxygenase type II
Synonyms 15-LOX-2
EC 1.13.11.33
8S-lipoxygenase
8S-LOX
Gene name
Name: Alox15b
Synonyms: Alox8
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
TISSUE=Epidermis;
DOI=10.1074/jbc.272.39.24410; PubMed=9305900 [NCBI, ExPASy, EBI, Israel, Japan]
Jisaka M., Kim R.B., Boeglin W.E., Nanney L.B., Brash A.R.;
"Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin.";
J. Biol. Chem. 272:24410-24416(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=NMRI;
TISSUE=Epidermis;
DOI=10.1016/S0005-2760(97)00214-2; PubMed=9518531 [NCBI, ExPASy, EBI, Israel, Japan]
Krieg P., Kinzig A., Heidt M., Marks F., Fuerstenberger G.;
"cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin.";
Biochim. Biophys. Acta 1391:7-12(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Skin;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U93277; AAC53356.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14696; CAA75003.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK028724; BAC26085.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC015253; AAH15253.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_033791.1; -.
UniGene Mm.289672
3D structure databases
HSSP P12530; 1LOX. [HSSP ENTRY / PDB]
ModBase O35936.
Organism-specific databases
MGI MGI:1098228; Alox8.
Gene expression databases
ArrayExpress O35936; -.
CleanEx MM_ALOX8; -.
GermOnline ENSMUSG00000020891; Mus musculus.
Ontologies
GO
GO:0005622; Cellular component: intracellular (inferred from sequence or structural similarity from UniProtKB).
GO:0050473; Molecular function: arachidonate 15-lipoxygenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0045786; Biological process: negative regulation of cell cycle (inferred from sequence or structural similarity from UniProtKB).
GO:0008285; Biological process: negative regulation of cell proliferation (inferred from sequence or structural similarity from UniProtKB).
GO:0045926; Biological process: negative regulation of growth (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR000907; LipOase.
IPR013819; LipOase_C.
IPR001024; LipOase_LH2.
IPR001885; LipOase_mml.
Graphical view of domain structure.
Gene3D G3DSA:2.60.60.20; Lipase_LipOase; 1.
PANTHER PTHR11771; LipOase; 1.
Pfam PF00305; Lipoxygenase; 1.
PF01477; PLAT; 1.
Pfam graphical view of domain structure.
PRINTS PR00087; LIPOXYGENASE.
PR00467; MAMLPOXGNASE.
SMART SM00308; LH2; 1.
SMART graphical view of domain structure.
PROSITE PS00711; LIPOXYGENASE_1; 1.
PS00081; LIPOXYGENASE_2; 1.
PS51393; LIPOXYGENASE_3; 1.
PS50095; PLAT; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O35936.
Genome annotation databases
Ensembl ENSMUSG00000020891; Mus musculus. [Contig view]
GeneID 11688; -.
KEGG mmu:11688; -.
Phylogenomic databases
HOGENOM O35936; -.
HOVERGEN O35936; -.
Other
SOURCE Alox15b; Mus musculus.
ProtoNet O35936.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Metal-binding; Oxidoreductase; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   677  677     Arachidonate 15-lipoxygenase type II. PRO_0000220701
DOMAIN   2   125  124     PLAT. 
DOMAIN   126   677  552     Lipoxygenase. 
METAL   374   374        Iron; catalytic (By similarity). 
METAL   379   379        Iron; catalytic (By similarity). 
METAL   554   554        Iron; catalytic (By similarity). 
METAL   677   677        Iron; via carboxylate; catalytic (By similarity). 
VARIANT   32    32  1     E -> G (in clone K12). 
VARIANT   38    38  1     L -> M (in clone G2). 
VARIANT   58    58  1     P -> R (in clone K12). 
VARIANT   76    76  1     V -> A (in clones G2, G5, G11 and K1). 
VARIANT   413   413  1     I -> V (in clone K7). 
VARIANT   536   536  1     R -> Q (in clones G2, G5 and G11). 
Sequence information
Length: 677 AA [This is the length of the unprocessed precursor] Molecular weight: 76230 Da [This is the MW of the unprocessed precursor] CRC64: 78DB1AC9C2F68399 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAKCRVRVST GEACGAGTWD KVSVSIVGTH GESPLVPLDH LGKEFSAGAE EDFEVTLPQD 

        70         80         90        100        110        120 
VGTVLMLRVH KAPPEVSLPL MSFRSDAWFC RWFELEWLPG AALHFPCYQW LEGAGELVLR 

       130        140        150        160        170        180 
EGAAKVSWQD HHPTLQDQRQ KELESRQKMY SWKTYIEGWP RCLDHETVKD LDLNIKYSAM 

       190        200        210        220        230        240 
KNAKLFFKAH SAYTELKVKG LLDRTGLWRS LREMRRLFNF RKTPAAEYVF AHWQEDAFFA 

       250        260        270        280        290        300 
SQFLNGINPV LIRRCHSLPN NFPVTDEMVA PVLGPGTSLQ AELEKGSLFL VDHGILSGVH 

       310        320        330        340        350        360 
TNILNGKPQF SAAPMTLLHQ SSGSGPLLPI AIQLKQTPGP DNPIFLPSDD TWDWLLAKTW 

       370        380        390        400        410        420 
VRNSEFYIHE AVTHLLHAHL IPEVFALATL RQLPRCHPLF KLLIPHIRYT LHINTLAREL 

       430        440        450        460        470        480 
LVAPGKLIDK STGLGTGGFS DLIKRNMEQL NYSVLCLPED IRARGVEDIP GYYYRDDGMQ 

       490        500        510        520        530        540 
IWGAIKSFVS EIVSIYYPSD TSVQDDQELQ AWVREIFSEG FLGRESSGMP SLLDTREALV 

       550        560        570        580        590        600 
QYITMVIFTC SAKHAAVSSG QFDSCVWMPN LPPTMQLPPP TSKGQARPES FIATLPAVNS 

       610        620        630        640        650        660 
SSYHIIALWL LSAEPGDQRP LGHYPDEHFT EDAPRRSVAA FQRKLIQISK GIRERNRGLA 

       670 
LPYTYLDPPL IENSVSI 

O35936 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!