NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9681435 [NCBI, ExPASy, EBI, Israel, Japan]
Boularand S., Biguet N.F., Vidal B., Veron M., Mallet J., Vincent J.D., Dufour S., Vernier P.;
"Tyrosine hydroxylase in the European eel (Anguilla anguilla): cDNA cloning, brain distribution, and phylogenetic analysis.";
J. Neurochem. 71:460-470(1998).

Comments

FUNCTION: Plays an important role in the physiology of adrenergic neurons (By similarity).
CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O₂ = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.
COFACTOR: Fe(2+) ion.
ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity (By similarity).
PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2 .
SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ000731; CAA04264.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P04177; 1TOH. [HSSP ENTRY / PDB]

SMR

O42091; 150-488.

ModBase

O42091.

Family and domain databases

InterPro

IPR001273; Aaa_hydroxylase.
IPR005962; Tyr_3_mOase.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.800.10; Aaa_hydroxylase; 1.

PANTHER

PTHR11473; Aaa_hydroxylase; 1.

Pfam

PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.

PRINTS

PR00372; FYWHYDRXLASE.

ProDom

PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01269; Tyr_3_monoox; 1.

PROSITE

PS00367; BIOPTERIN_HYDROXYL; 1.

BLOCKS

O42091.

Phylogenomic databases

HOVERGEN

O42091; -.

Other

ProtoNet

O42091.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Catecholamine biosynthesis; Iron; Metal-binding; Monooxygenase; Neurotransmitter biosynthesis; Oxidoreductase; Phosphoprotein.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 488`	`488`	`Tyrosine 3-monooxygenase.`	`PRO_0000205559`
`METAL`	`321 321`		`Iron (By similarity).`
`METAL`	`326 326`		`Iron (By similarity).`
`METAL`	`366 366`		`Iron (By similarity).`
`MOD_RES`	`38 38`		`Phosphoserine; by PKA (By similarity).`

Sequence information

Length: 488 AA [This is the length of the unprocessed precursor]

Molecular weight: 55490 Da [This is the MW of the unprocessed precursor]

CRC64: 573553BA39EBD448 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPISNSSGSS TKSITRAGSE LDRADSITSP RFVGRRQSLI EDARKEREAA AAAESSEASE 

        70         80         90        100        110        120 
QIVFDEEDGK ALLNLFFTLR SSKIPALSRA LKVFETFEAK IHHLETRTRR KPKDSLEDLE 

       130        140        150        160        170        180 
YFVRCEVHLA DVSTLISSIR RIAEDVRTTK EVKFHWFPKK ISELDSCHHL VTKFDPDLDQ 

       190        200        210        220        230        240 
DHPGFTDPVY RQRRRMIGEI AFRYKHGEPI PRVEYTEEEI GTWREVYSTL RDLYTTHACS 

       250        260        270        280        290        300 
EHLEAFRLLE RHCGYSPNSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF LASLAFRVFQ 

       310        320        330        340        350        360 
CTQYIRHASS PMHSPEPDCV HELLGHVPML ADRTFAQFSQ NIGLASLGAS EEDIEKLSTL 

       370        380        390        400        410        420 
YWFTVEFGLC KQGDGVKAYG AGLLSSYGEL VHSLSDEPER REFDPEAAAA EPYQDQNYQS 

       430        440        450        460        470        480 
VYFVSESFTD AKEKLRVYAA GINRPFSVRF DPYTYSIEVL DNPLKIRGGL ESVKDELKVL 


TDALNVLA

O42091 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools