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UniProtKB/Swiss-Prot entry O59711


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LYS9_SCHPO
Primary accession number O59711
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 34)
Name and origin of the protein
Protein name Saccharopine dehydrogenase [NADP+, L-glutamate-forming]
Synonyms EC 1.5.1.10
Saccharopine reductase
Gene name
Name: lys9
ORFNames: SPBC3B8.03
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nbt1222; PubMed=16823372 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329671; CAA18292.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T40337; T40337.
RefSeq NP_596411.1; -.
3D structure databases
HSSP Q9P4R4; 1FF9. [HSSP ENTRY / PDB]
ModBase O59711.
Organism-specific databases
GeneDB_Spombe SPBC3B8.03; -.
Gene expression databases
ArrayExpress O59711; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR005097; Saccharopine_DHase.
Graphical view of domain structure.
Pfam PF03435; Saccharop_dh; 1.
Pfam graphical view of domain structure.
BLOCKS O59711.
Genome annotation databases
GeneID 2540908; -.
KEGG spo:SPBC3B8.03; -.
NMPDR fig|4896.1.peg.2277; -.
Other
ProtoNet O59711.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Lysine biosynthesis; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   450  450     Saccharopine dehydrogenase [NADP+, L-glutamate-forming]. PRO_0000316856
Sequence information
Length: 450 AA [This is the length of the unprocessed precursor] Molecular weight: 49938 Da [This is the MW of the unprocessed precursor] CRC64: 1AEE17A423715C71 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPSILLLGSG FVAHPTLEYL SRRKENNITV ACRTLSKAEA FINGIPNSKA IALDVNDEAA 

        70         80         90        100        110        120 
LEKAVSEHDL TISLIPYTYH ATVMKAAIKH GKHVCTTSYV NPKMAELEEA AIKAGSICMN 

       130        140        150        160        170        180 
EIGVDPGIDH LYAIKTIEEV HKAGGKIKSF LSYCGGLPAP EDSNNPLGYK FSWSSRGVLL 

       190        200        210        220        230        240 
ALRNSAKFYE NGKLVEIDGK DLMETAKPYF IYPGYAFVCY PNRDSTVYQE RYQIPEAETI 

       250        260        270        280        290        300 
IRGTLRYQGF PEFIHCLVDM GFLDETAQEY LSPEAPALPW KEVTARVIKA ESSSEADLIK 

       310        320        330        340        350        360 
KISSIHKFKD EDDKKRILNG LKWLGMFSSK PVTPRGNPLD TLCATLEELM QYEEGERDML 

       370        380        390        400        410        420 
ILQHKFEVET KEGKRQTRTC TLLDYGVPNG YTSMAKLVGV PCGVATQQIL DGVINTPGVL 

       430        440        450 
APNDMKLCGP LIDTLAKEGI RLEEEIIDEE 

O59711 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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