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UniProtKB/Swiss-Prot entry O61235

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CATA2_CAEEL
Primary accession number O61235
Secondary accession numbers O18193 Q9XVZ4
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on November 25, 2002 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 64)
Name and origin of the protein
Protein name Catalase-2
Synonym EC 1.11.1.6
Gene name
Name: ctl-1
Synonyms: cat-2
ORFNames: Y54G11A.6
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=Bristol N2;
DOI=10.1038/20208; PubMed=10335847 [NCBI, ExPASy, EBI, Israel, Japan]
Taub J., Lau J.F., Ma C., Hahn J.H., Hoque R., Rothblatt J., Chalfie M.;
"A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.";
Nature 399:162-166(1999).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=Bristol N2;
Eckelt V.H.O.;
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
  • FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Responsible for the increase in catalase activity detected in dauer larvae. May act as a general scavenger of hydrogen peroxide in the cytosol, or it may protect cells from the effects of an unknown, dauer-specific metabolic process. Expression may be directly regulated by daf-16.
  • CATALYTIC ACTIVITY: 2 H2O2 = O2 + 2 H2O.
  • COFACTOR: Heme group.
  • SUBCELLULAR LOCATION: Cytoplasm.
  • DEVELOPMENTAL STAGE: With abundant food, the amount of ctl-1 decreases slightly as worms mature.
  • INDUCTION: Overcrowding and depletion of food.
  • SIMILARITY: Belongs to the catalase family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U55384; AAC14537.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14066; CAA74394.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14065; CAA74392.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL034488; CAA22458.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T37477; T37477.
T42443; T42443.
RefSeq NP_496979.2; -.
UniGene Cel.34211
3D structure databases
HSSP P04040; 1F4J. [HSSP ENTRY / PDB]
ModBase O61235.
Organism-specific databases
WormBase WBGene00000830; ctl-1.
WormPep Y54G11A.6; CE30713. [WormPep / WorfDB]
Gene expression databases
ArrayExpress O61235; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (non-traceable author statement from UniProtKB).
GO:0004096; Molecular function: catalase activity (inferred from mutant phenotype from UniProtKB).
GO:0008340; Biological process: determination of adult life span (inferred from mutant phenotype from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.
Gene3D G3DSA:2.40.180.10; Catalase_N; 1.
PANTHER PTHR11465; Catalase; 1.
Pfam PF00199; Catalase; 1.
Pfam graphical view of domain structure.
PRINTS PR00067; CATALASE.
ProDom PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.
BLOCKS O61235.
Genome annotation databases
Ensembl Y54G11A.6; Caenorhabditis elegans. [Contig view]
GeneID 259738; -.
KEGG cel:Y54G11A.6; -.
NMPDR fig|6239.3.peg.8173; -.
Other
ProtoNet O61235.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   497  497     Catalase-2. PRO_0000084910
ACT_SITE   71    71        By similarity. 
ACT_SITE   144   144        By similarity. 
METAL   354   354        Iron (heme axial ligand) (By similarity). 
CONFLICT   91    91        C -> G (in Ref. 1; AAC14537). 
CONFLICT   97    97        N -> H (in Ref. 1; AAC14537). 
CONFLICT   190   190        Missing (in Ref. 1; AAC14537). 
CONFLICT   237   237        G -> P (in Ref. 1; AAC14537). 
CONFLICT   270   270        F -> L (in Ref. 1; AAC14537). 
CONFLICT   282   282        F -> I (in Ref. 1; AAC14537). 
CONFLICT   310   310        G -> A (in Ref. 1; AAC14537). 
CONFLICT   313   313        V -> L (in Ref. 1; AAC14537). 
CONFLICT   385   386        DG -> EV (in Ref. 2; CAA74394/CAA74392). 
CONFLICT   394   395        GD -> EN (in Ref. 2; CAA74394/CAA74392). 
CONFLICT   399   399        Y -> S (in Ref. 2; CAA74394/CAA74392). 
CONFLICT   425   428        DRYE -> GSLW (in Ref. 1; AAC14537). 
Sequence information
Length: 497 AA [This is the length of the unprocessed precursor] Molecular weight: 57305 Da [This is the MW of the unprocessed precursor] CRC64: 26662FE6EF38CCE5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPNDPSDNQL KTYKETYPKP QVITTSNGAP IYSKTAVLTA GRRGPMLMQD VVYMDEMAHF 

        70         80         90        100        110        120 
DRERIPERVV HAKGAGAHGY FEVTHDITKY CKADMFNKVG KQTPLLVRFS TVAGESGSAD 

       130        140        150        160        170        180 
TVRDPRGFSL KFYTEEGNWD LVGNNTPIFF IRDAIHFPNF IHALKRNPQT HMRDPNALFD 

       190        200        210        220        230        240 
FWMNRPESIH QVMFLYSDRG IPDGFRFMNG YGAHTFKMVN KEGNPIYCKF HFKPAQGSKN 

       250        260        270        280        290        300 
LDPTDAGKLA SSDPDYAIRD LFNAIESRNF PEWKMFIQVM TFEQAEKWEF NPFDVTKVWP 

       310        320        330        340        350        360 
HGDYPLIEVG KMVLNRNVKN YFAEVEQAAF CPAHIVPGIE FSPDKMLQGR IFSYTDTHYH 

       370        380        390        400        410        420 
RLGPNYIQLP VNCPYRSRAH TTQRDGAMAY ESQGDAPNYF PNSFRGYRTR DDVKESTFQT 

       430        440        450        460        470        480 
TGDVDRYETG DDHNYEQPRQ FWEKVLKEEE RDRLVGNLAS DLGGCLEEIQ NGMVKEFTKV 

       490 
HPDFGNALRH QLCQKKH
O61235 in FASTA format

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