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UniProtKB/Swiss-Prot entry O64966

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH1_GOSHI
Primary accession number O64966
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 60)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Synonyms HMG-CoA reductase 1
EC 1.1.1.34
Gene name
Name: HMG1
From
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) [TaxID: 3635] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Malvales; Malvaceae; Malvoideae; Gossypium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=cv. Acala SJ2;
Loguercio L.L., Wilkins T.A.;
"Two genomic clones encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase from cotton (Gossypium hirsutum L.).";
(er) Plant Gene Register PGR98-031.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF038045; AAC05088.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T09782; T09782.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase O64966.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0042170; Cellular component: plastid membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS O64966.
Other
ProtoNet O64966.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; Mitochondrion; NADP; Oxidoreductase; Plastid; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   585  585     3-hydroxy-3-methylglutaryl-coenzyme A reductase 1. PRO_0000114438
TRANSMEM   38    58  21     Potential. 
TRANSMEM   77    97  21     Potential. 
REGION   98   169  72     Linker (By similarity). 
REGION   170   585  416     Catalytic (By similarity). 
ACT_SITE   264   264        Charge relay system (By similarity). 
ACT_SITE   396   396        Charge relay system (By similarity). 
ACT_SITE   472   472        Charge relay system (By similarity). 
ACT_SITE   570   570        Proton donor (By similarity). 
CARBOHYD   328   328        N-linked (GlcNAc...) (Potential). 
CARBOHYD   441   441        N-linked (GlcNAc...) (Potential). 
CARBOHYD   574   574        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 585 AA [This is the length of the unprocessed precursor] Molecular weight: 62835 Da [This is the MW of the unprocessed precursor] CRC64: 1350E7A9168EBE42 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
METHRRSSTN SIRSHKPARP IALEDDSTKA SDALPLPLYL TNAVFFTLFF SAVYFLLCRW 

        70         80         90        100        110        120 
REKIRSSTPL HVVTFSEIVA ILASVASFIY LLGFFGIDFV QSLVLRPSAD VWATEDDEVE 

       130        140        150        160        170        180 
SEVLLRNEDA RHVPCGQALD RSIRSLQPPE PIVTAEKVFD EMPVTVMTEE DEEIIRSVVC 

       190        200        210        220        230        240 
GMTPSYSLES KLDDCKRAAA IRREALQRIT GKSLSGLPLD GFDYESILGQ CCEMPVGYEQ 

       250        260        270        280        290        300 
IPVGIAGPLL LNGREYSVPM ATTEGCLVAS TNRGCKAIHL SGGATSVLLR DGMTRAPVVR 

       310        320        330        340        350        360 
FGTAKRAADL KLYLEDPENF ETLACVFNRS SRFARLQSIK CAIAGKNLYL RFSCFTGDAM 

       370        380        390        400        410        420 
GMNMVSKGVQ NVLDFLQTDF PDMDVIGISG NFCSDKKPAA VNWIEGRGKS VVCEAIINGD 

       430        440        450        460        470        480 
VVTKVLKTSV ESLVELNMLK NLTGSAMAGA LGGFNAHASN IVTAVYIATG QDPAQNVESS 

       490        500        510        520        530        540 
HCITMMEAVN GGKDLHVSVT MPSIEVGTVG GGTQLASQSA CLNLLGVKGA SKESPGANSI 

       550        560        570        580 
LLATIVAGAV LAGELSLMSA LAAGQLVKSH MKYNRSSKDV SKVSS
O64966 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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